{"product_id":"myl2-antibody-myosin-regulatory-light-chain-2-bha17135968","title":"MYL2 Antibody \/ Myosin regulatory light chain 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eMYL2 Antibody \/ Myosin regulatory light chain 2 is a anti-MYL2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Monkey, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e MYL2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eMYL2 antibody detects myosin regulatory light chain 2, a contractile protein critical for cardiac and skeletal muscle contraction. The UniProt recommended name is Myosin regulatory light chain 2 (MYL2). This 166-amino-acid protein binds to the neck region of myosin heavy chain, stabilizing the lever-arm structure and modulating actin-activated ATPase activity during force generation.\u003cbr\u003e\u003cbr\u003eFunctionally, MYL2 antibody identifies a calcium-binding protein that undergoes phosphorylation by myosin light chain kinase (MLCK) at serine 15. Phosphorylation increases calcium sensitivity and enhances contractile force, playing a vital role in excitation-contraction coupling. MYL2 expression is strongest in cardiac ventricles, distinguishing it from atrial isoforms such as MYL7. Its presence marks ventricular myocytes in both mature and differentiating cardiac tissue.\u003cbr\u003e\u003cbr\u003eThe MYL2 gene resides on chromosome 12q24.11 and encodes a regulatory component of the myosin complex. Mutations in MYL2 have been associated with familial hypertrophic cardiomyopathy, left ventricular dysfunction, and sudden cardiac death. These variants alter protein folding or phosphorylation sites, impairing actomyosin cross-bridge cycling and contractile mechanics.\u003cbr\u003e\u003cbr\u003eIn muscle physiology, MYL2 acts as a fine-tuner of myosin motor function, adjusting contraction kinetics through dynamic phosphorylation. In developmental studies, MYL2 serves as a ventricular differentiation marker, while in pathology it reflects remodeling in cardiac hypertrophy and failure. Experimental models using MYL2 antibody provide insights into sarcomere assembly, cardiomyocyte maturation, and myofibrillar alignment.\u003cbr\u003e\u003cbr\u003eMYL2 antibody is suitable for western blotting, immunohistochemistry, and immunofluorescence to detect cardiac myosin light chain expression. It is extensively used in cardiovascular research, muscle biology, and regenerative medicine to monitor contractile protein regulation. \u003cbr\u003e\u003cbr\u003eStructurally, MYL2 belongs to the EF-hand calcium-binding family and interacts with the IQ motif of myosin heavy chains. Its N-terminal domain modulates ATP hydrolysis and contributes to sarcomeric order. This antibody enables precise detection of MYL2 to study contractile regulation, disease mechanisms, and cardiomyocyte differentiation.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=MYL2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=MYL2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=MYL2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/MYL2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=MYL2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047311303021,"sku":"FY13066","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_a280ecaf-7ac4-49fa-9dae-087f7a52503f.jpg?v=1782237077","url":"https:\/\/www.ebiohippo.com\/products\/myl2-antibody-myosin-regulatory-light-chain-2-bha17135968","provider":"BioHippo","version":"1.0","type":"link"}