{"product_id":"myo1b-antibody-myosin-ib-bha17135318","title":"MYO1B Antibody \/ Myosin IB","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eMYO1B Antibody \/ Myosin IB is a anti-MYO1B Rabbit antibody Recombinant Rabbit Monoclonal clone 30M16 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e MYO1B\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 30M16, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eMYO1B antibody recognizes myosin IB, a member of the class I myosins encoded by the MYO1B gene. Myosin IB is a monomeric actin based motor protein that uses ATP hydrolysis to generate mechanical force. Unlike conventional myosins, class I myosins lack the ability to form filaments and instead function as membrane associated motors. MYO1B contains a motor domain that interacts with actin filaments, a neck domain with calmodulin binding IQ motifs, and a tail domain that anchors the protein to cellular membranes. Through these features, MYO1B contributes to membrane trafficking, endocytosis, and cytoskeletal organization.\u003cbr\u003e\u003cbr\u003eMYO1B antibody is widely used in studies of cell motility, intracellular trafficking, and actin cytoskeleton dynamics. The protein is expressed in a variety of tissues, with high levels found in brain, kidney, and epithelial cells. MYO1B regulates actin dependent processes including lamellipodia extension and endocytic vesicle transport. By detecting MYO1B, researchers can explore how actin motor proteins coordinate signaling and transport at the plasma membrane.\u003cbr\u003e\u003cbr\u003eThe antibody is suitable for western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. In western blot assays, MYO1B antibody identifies protein bands of expected molecular weight, enabling quantitative assessment of expression. Immunohistochemistry reveals strong staining at actin rich regions of cells and tissues. Immunofluorescence studies highlight dynamic localization of MYO1B in lamellipodia, endocytic vesicles, and actin filament networks.\u003cbr\u003e\u003cbr\u003eMYO1B has been implicated in neuronal development, where it contributes to neurite outgrowth and synaptic remodeling. It also plays roles in epithelial polarity and vesicle trafficking, influencing processes such as nutrient uptake and receptor internalization. Dysregulation of MYO1B has been linked to cancer progression, where altered actin dynamics promote invasion and metastasis. By using MYO1B antibody, scientists can evaluate how myosin IB expression changes in development and disease.\u003cbr\u003e\u003cbr\u003eIn kidney physiology, MYO1B regulates endocytic pathways that control protein reabsorption. Defects in this process may contribute to renal disorders. In cancer research, increased MYO1B activity has been associated with enhanced migratory capacity of tumor cells. Detecting MYO1B with specific antibodies provides insight into how actin motor proteins contribute to both physiological and pathological outcomes.\u003cbr\u003e\u003cbr\u003eMYO1B antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=MYO1B - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=MYO1B - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=MYO1B - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/MYO1B - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=MYO1B+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047288267117,"sku":"FY12415","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_fd8c7822-aba2-465a-bebc-eff7860b3e4f.jpg?v=1772019289","url":"https:\/\/www.ebiohippo.com\/products\/myo1b-antibody-myosin-ib-bha17135318","provider":"BioHippo","version":"1.0","type":"link"}