{"product_id":"myorg-antibody-myogenesis-regulating-glycosidase-bha17136019","title":"MYORG Antibody \/ Myogenesis-regulating glycosidase","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eMYORG Antibody \/ Myogenesis-regulating glycosidase is a anti-MYORG Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e MYORG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eMYORG antibody detects Myogenesis-regulating glycosidase, a lysosomal and endoplasmic reticulum-associated enzyme involved in protein processing and neurological function. The UniProt recommended name is Myogenesis-regulating glycosidase (MYORG). This glycosidase is highly conserved and plays a crucial role in the maintenance of glycoprotein homeostasis within neural tissues, particularly astrocytes.\u003cbr\u003e\u003cbr\u003eFunctionally, MYORG antibody identifies a 714-amino-acid glycosidase belonging to the glycosyl hydrolase family 31. MYORG hydrolyzes terminal sugar residues from oligosaccharides and glycoproteins, participating in lysosomal degradation and protein quality control. It is mainly localized to the endoplasmic reticulum and perinuclear regions, suggesting involvement in post-translational processing rather than extracellular digestion.\u003cbr\u003e\u003cbr\u003eThe MYORG gene is located on chromosome 9p13.1 and is highly expressed in brain and skeletal muscle. In the central nervous system, MYORG supports astrocyte differentiation and intercellular communication. It is co-regulated with genes controlling lysosomal activity, endoplasmic reticulum homeostasis, and metabolic signaling.\u003cbr\u003e\u003cbr\u003ePathologically, mutations in MYORG cause primary familial brain calcification (PFBC), a neurodegenerative disorder characterized by calcium deposits in basal ganglia and cerebellum. Deficiency in MYORG leads to altered glycosylation and impaired protein turnover in astrocytes. Research using MYORG antibody assists studies of glycoprotein metabolism, lysosomal function, and neurological disease mechanisms.\u003cbr\u003e\u003cbr\u003eMYORG antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect intracellular glycosidases and neuronal processing enzymes. \u003cbr\u003e\u003cbr\u003eStructurally, Myogenesis-regulating glycosidase contains a catalytic domain typical of glycosyl hydrolases with conserved acid-base residues, and a C-terminal transmembrane region anchoring it to intracellular membranes. This antibody supports analysis of MYORG's biochemical function and contribution to neurodegenerative disorders.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=MYORG - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=MYORG - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=MYORG - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/MYORG - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=MYORG+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047314710893,"sku":"FY13117","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_67eefc50-13bc-4c6b-8d8c-5f481b2f8e58.jpg?v=1782237109","url":"https:\/\/www.ebiohippo.com\/products\/myorg-antibody-myogenesis-regulating-glycosidase-bha17136019","provider":"BioHippo","version":"1.0","type":"link"}