{"product_id":"myosin-binding-protein-c-antibody-mybpc3-bha17128165","title":"Myosin-binding protein C Antibody \/ MYBPC3","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eMyosin-binding protein C Antibody \/ MYBPC3 is an antibody targeting \u003cstrong\u003eMYBPC3\u003c\/strong\u003e, raised in \u003cstrong\u003eRabbit\u003c\/strong\u003e for protein detection and localization studies where these specifications are required.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e MYBPC3.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Polyclonal (rabbit origin); Rabbit Ig.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/label:\u003c\/strong\u003e Unconjugated (affects detection chemistry and multiplex compatibility).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Human, Mouse, Rat.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eListed applications:\u003c\/strong\u003e WB, IHC-P (refer to on-page specifications for application-specific guidance).\u003c\/li\u003e \u003c\/ul\u003e  \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eMyosin-binding protein C is a thick filament-associated protein that interacts with myosin and actin to regulate muscle contraction. It acts as a molecular ruler, fine-tuning the interactions between myosin and actin to ensure proper muscle function. MYBPC3 mutations can disrupt this delicate balance, leading to impaired muscle contraction and potential cardiac complications. Mutations in the MYBPC3 gene have been associated with hypertrophic cardiomyopathy (HCM), a condition characterized by thickening of the heart muscle. These mutations can disrupt the normal function of Myosin-binding protein C, leading to abnormal muscle contraction and potentially life-threatening complications.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eComparative expression profiling across cell types, tissues, or perturbations (e.g., drug treatment, genetic editing, or differentiation).\u003c\/li\u003e \u003cli\u003eSubcellular localization and trafficking studies, including co-localization with pathway markers in microscopy-based assays.\u003c\/li\u003e \u003cli\u003eIntegration of protein-level measurements with transcriptomics or proteomics to relate abundance to regulation and phenotype.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eWestern blotting: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003cli\u003eImmunohistochemistry: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eInterpretation should account for antibody-dependent factors such as epitope accessibility, isoforms, and sample preparation differences across workflows.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eIsoforms and PTMs:\u003c\/strong\u003e many targets have multiple isoforms and post-translational modifications that can shift apparent signal or localization; interpret bands\/signals accordingly.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eEpitope context:\u003c\/strong\u003e binding can depend on protein conformation and sample processing; region information in the title\/immunogen can help anticipate what may be detected.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies differences:\u003c\/strong\u003e predicted or validated reactivity may vary by ortholog sequence and sample context; confirm in your model system.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eControl concepts:\u003c\/strong\u003e include negative controls (no-primary\/isotype), and where possible genetic controls (KO\/KD) or independent antibodies to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProtKB entry Q14896 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/Q14896 - Gene search: MYBPC3 — NCBI Gene — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=MYBPC3 - Ensembl search: MYBPC3 — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=MYBPC3 - PubMed search: MYBPC3 antibody — PubMed — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=MYBPC3+antibody - Reactome search: MYBPC3 — Reactome — https:\/\/reactome.org\/content\/query?q=MYBPC3 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.08 ml","offer_id":53046409265517,"sku":"F55102-0.08ML","price":205.0,"currency_code":"USD","in_stock":true},{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.4 ml","offer_id":53046470181229,"sku":"F55102-0.4ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_91dfff1a-2d7f-4ab9-a86c-8177c2b7f9cd.jpg?v=1772000494","url":"https:\/\/www.ebiohippo.com\/products\/myosin-binding-protein-c-antibody-mybpc3-bha17128165","provider":"BioHippo","version":"1.0","type":"link"}