{"product_id":"nav1-antibody-neuron-navigator-1-bha17136211","title":"NAV1 Antibody \/ Neuron navigator 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eNAV1 Antibody \/ Neuron navigator 1 is a anti-NAV1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA with listed reactivity in Human. Reported localization: Cytoplasm (cytoskeleton).\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NAV1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, IF, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eNAV1 antibody detects Neuron navigator 1, a cytoplasmic and microtubule-associated protein encoded by the NAV1 gene on chromosome 1q32.1. NAV1 belongs to the neuron navigator family of cytoskeletal regulators that guide neuronal migration, axon pathfinding, and cell motility. Structurally, NAV1 contains a calponin homology (CH) domain, coiled-coil regions, and a C-terminal AAA ATPase domain that enable its interaction with actin filaments and microtubules. These domains provide NAV1 with the ability to influence cytoskeletal organization and intracellular transport dynamics, particularly during nervous system development.\u003cbr\u003e\u003cbr\u003eNAV1 antibody identifies a protein that localizes primarily in the cytoplasm and along microtubule tracks, where it regulates growth cone navigation and neurite extension. The NAV1 protein interacts with microtubule plus-end tracking proteins (+TIPs) and motor proteins to guide axonal growth toward appropriate targets. It is expressed in neurons, glial cells, and various epithelial tissues, with high expression observed in the developing brain, spinal cord, and retina. Through its coordination of cytoskeletal dynamics, NAV1 contributes to processes such as neuronal polarization, synaptic connectivity, and axon regeneration.\u003cbr\u003e\u003cbr\u003eThe NAV1 gene produces several isoforms via alternative splicing, allowing tissue-specific regulation of its functions. NAV1 also participates in non-neuronal cell migration and wound healing by influencing actin remodeling and focal adhesion turnover. The protein's CH domain mediates actin binding, while its ATPase domain is thought to regulate conformational changes during cytoskeletal rearrangement. NAV1 functions in signaling pathways controlled by small GTPases such as Rac1 and Cdc42, which govern directional cell movement and axonal pathfinding.\u003cbr\u003e\u003cbr\u003eClinical research links NAV1 dysregulation to neurodevelopmental disorders and brain tumors. Genetic studies have associated NAV1 variants with autism spectrum disorders and schizophrenia, suggesting roles in neuronal wiring and cortical organization. In gliomas, altered NAV1 expression correlates with tumor cell invasiveness, consistent with its role in motility regulation. Additionally, NAV1 is implicated in axon regeneration following injury, making it a potential therapeutic target for neurorepair strategies.\u003cbr\u003e\u003cbr\u003eStructurally, the AAA ATPase-like domain of NAV1 shares similarity with microtubule-severing enzymes, though it lacks catalytic residues, indicating a structural or regulatory rather than enzymatic role. Its large size and multi-domain nature allow it to serve as a scaffold linking actin and microtubule cytoskeletons. NAV1 is also thought to influence intracellular transport of signaling endosomes and synaptic vesicles in neurons. The gene's expression is developmentally regulated by transcription factors including CREB and NFAT, reflecting its integration into neuronal growth programs.\u003cbr\u003e\u003cbr\u003eImmunohistochemical staining using NAV1 antibody shows cytoplasmic and perinuclear localization in neurons and glial cells, with prominent labeling in axons and dendritic projections. NAV1 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=NAV1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=NAV1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=NAV1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/NAV1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=NAV1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047321428333,"sku":"FY13309","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_b26337d2-49f6-4238-a48a-186c02ae0efe.jpg?v=1782237090","url":"https:\/\/www.ebiohippo.com\/products\/nav1-antibody-neuron-navigator-1-bha17136211","provider":"BioHippo","version":"1.0","type":"link"}