{"product_id":"nav3-antibody-neuron-navigator-3-bha17135701","title":"NAV3 Antibody \/ Neuron navigator 3","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eNAV3 Antibody \/ Neuron navigator 3 is a anti-NAV3 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NAV3\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eNAV3 antibody detects Neuron navigator 3, a cytoskeletal-associated protein that regulates axon guidance, neuronal migration, and cytoskeletal organization. Encoded by the NAV3 gene on chromosome 12q21.2, this protein belongs to the neuron navigator family, which also includes NAV1 and NAV2, and is characterized by coiled-coil and calponin homology domains that facilitate interaction with microtubules and actin filaments. NAV3 plays a pivotal role in neuronal development and guidance by stabilizing the cytoskeleton and modulating microtubule dynamics during axon extension.\u003cbr\u003e\u003cbr\u003eNAV3 localizes primarily to neuronal growth cones and extending axons, where it influences the assembly and organization of cytoskeletal networks required for directional growth. It interacts with signaling molecules involved in cytoskeletal regulation, including Rho GTPases and kinases that modulate actin-microtubule coordination. Beyond its developmental roles, NAV3 contributes to cytoskeletal remodeling in mature neurons and glial cells, supporting plasticity and response to injury.\u003cbr\u003e\u003cbr\u003eThe NAV3 antibody is used in neuroscience and developmental biology research to study axon formation, neuronal polarity, and migration. Western blot analysis identifies a 250 kilodalton band corresponding to NAV3, while immunofluorescence reveals punctate and filamentous staining along axons and dendritic processes. This antibody enables detailed visualization of cytoskeletal organization and neuronal network formation.\u003cbr\u003e\u003cbr\u003eAltered NAV3 expression is associated with neurodevelopmental disorders, epilepsy, and gliomas, where disrupted cytoskeletal control affects cell morphology and migration. Additionally, NAV3 has been linked to wound healing and skin differentiation, as its expression is upregulated during keratinocyte migration. The NAV3 antibody provides a robust tool for analyzing cytoskeletal guidance mechanisms and neuronal development.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=NAV3 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=NAV3 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=NAV3 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/NAV3 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=NAV3+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047300129133,"sku":"FY12799","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_d95c923d-9448-4b0c-b422-e9aee58cfedb.jpg?v=1782237042","url":"https:\/\/www.ebiohippo.com\/products\/nav3-antibody-neuron-navigator-3-bha17135701","provider":"BioHippo","version":"1.0","type":"link"}