{"product_id":"nax-5055-bhb21300249","title":"NAX-5055","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C104H174N24O22.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso known as:\u003c\/strong\u003e Gal-B2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular weight:\u003c\/strong\u003e 2112.6 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;98% (HPLC)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1-100 nM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in DMSO. Centrifuge all products before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e Galanin Receptors\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e NAX-5055, a systemically active analogue of the endogenous neuropeptide galanin, is a high affinity galanin receptors ligand (Ki=3.5 nM and 51.5 nM for GalR1 and GalR2, respectively), shown to prevent seizures in mouse epilepsy model in vivo1,2.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names:\u003c\/strong\u003e Gal-B2\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eNAX-5055 is an active analog of the endogenous neuropeptide galanin that acts as a galanin receptor 1 (GalR1) and galanin receptor 2 (GalR2) agonist. NAX-5055 demonstrates high affinity for the receptors and was shown to prevent seizures in mouse model of epilepsy following intraperitoneal administration1.NAX-5055 is a systemically-active, metabolically stable galanin analog that can penetrate the blood-brain-barrier and displays a potent anticonvulsant activity2,3.Galanin is widely expressed throughout the central and peripheral nervous systems. Galanin receptors belong to the family of G-protein coupled receptors. Studies show that galanin and its receptors are involved in the transmission and modulation of nociception in the central nervous system, at spinal cord levels and in the brain4.\u003c\/p\u003e \u003ch3\u003eModifications\u003c\/h3\u003e \u003cp\u003eN-terminal glycine is substituted with sarcosine. Lys at position 16 is palmitoylated. C-terminal amidation.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003ch3\u003eSequence\u003c\/h3\u003e \u003cpre\u003e(Sar)WTLNSAGYLLGPKKK(pal)K-NH2.\u003c\/pre\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249712128365,"sku":"N-360-10MG-1","price":406.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311567954285,"sku":"N-360-25MG-1","price":747.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311567987053,"sku":"N-360-5MG-1","price":235.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311568019821,"sku":"N-360-50MG-1","price":1153.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/N-360_gr.gif?v=1778544442","url":"https:\/\/www.ebiohippo.com\/products\/nax-5055-bhb21300249","provider":"BioHippo","version":"1.0","type":"link"}