{"product_id":"ncc-antibody-bha11907786","title":"NCC Antibody","description":"\u003cp\u003eThe Na⁺-Cl⁻ co-transporter (NCC), primarily expressed in the distal convoluted tubule of the kidney, is a thiazide-sensitive transporter critical for sodium and chloride reabsorption. While traditionally studied in renal physiology and hypertension, emerging evidence suggests that NCC may also play a role in neurodegenerative disease through its influence on systemic electrolyte balance and neuronal excitability.\u003c\/p\u003e\n\n\u003cp\u003eNCC is activated by phosphorylation and regulated by signaling pathways involving SGK1 and WNK kinases. Dysregulation of NCC activity can alter extracellular potassium and sodium levels, indirectly affecting neuronal membrane potential and synaptic transmission. Additionally, NCC expression has been detected in non-renal tissues, including the lens and possibly the brain, suggesting broader physiological roles.\u003c\/p\u003e\n\n\u003cp\u003eIn neurodegenerative contexts, electrolyte imbalance and altered ion transport are known contributors to neuronal dysfunction and glial activation. NCC-mediated sodium handling may influence neuroinflammatory responses and oxidative stress, particularly in conditions such as Alzheimer’s disease and vascular dementia. Furthermore, thiazide diuretics targeting NCC have been associated with cognitive effects, underscoring the transporter’s potential relevance in brain health.\u003c\/p\u003e\n\n\u003cp\u003eUnderstanding NCC’s extrarenal functions may reveal novel mechanisms linking ion transport to neurodegeneration and offer new therapeutic avenues for modulating neuronal homeostasis.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug \/ Unconjugated","offer_id":53040794468717,"sku":"SPC-402D","price":348.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 390","offer_id":53040879272301,"sku":"SPC-402D-A390","price":403.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 488","offer_id":53040879305069,"sku":"SPC-402D-A488","price":402.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 594","offer_id":53040879337837,"sku":"SPC-402D-A594","price":402.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ APC","offer_id":53040879370605,"sku":"SPC-402D-APC","price":401.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ BI","offer_id":53040879403373,"sku":"SPC-402D-BI","price":397.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ FITC","offer_id":53040879436141,"sku":"SPC-402D-FITC","price":393.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ HRP","offer_id":53040879468909,"sku":"SPC-402D-HRP","price":389.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ PCP","offer_id":53040879501677,"sku":"SPC-402D-PCP","price":401.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ RPE","offer_id":53040879534445,"sku":"SPC-402D-RPE","price":399.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040879567213,"sku":"SPC-402S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SPC-402_NCC_Antibody_IHC_Rat_kidney-tissue_2.png?v=1771832159","url":"https:\/\/www.ebiohippo.com\/products\/ncc-antibody-bha11907786","provider":"BioHippo","version":"1.0","type":"link"}