{"product_id":"ncdn-antibody-neurochondrin-bha17135578","title":"NCDN Antibody \/ Neurochondrin","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eNCDN Antibody \/ Neurochondrin is a anti-NCDN Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NCDN\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eNCDN antibody recognizes Neurochondrin, a cytoplasmic protein that modulates neuronal differentiation, receptor signaling, and synaptic plasticity. Neurochondrin is widely expressed in the central nervous system, including the hippocampus, cerebellum, and cerebral cortex, where it influences long-term synaptic potentiation and memory formation. The protein functions as a negative regulator of metabotropic glutamate receptor 5 (mGluR5) signaling by interacting with G-protein coupled receptor complexes, thereby controlling calcium homeostasis and dendritic spine development. During neural differentiation, Neurochondrin promotes neurite outgrowth and cytoskeletal organization, making it a key factor in neuronal morphogenesis.\u003cbr\u003e\u003cbr\u003eNeurochondrin, encoded by the NCDN gene on chromosome 12q13.3, is approximately 79 kilodaltons in size and highly conserved among vertebrates. It is enriched in postmitotic neurons and functions as a scaffold linking cell surface receptors with intracellular signaling cascades. The protein associates with calmodulin and modulates calcium-dependent processes critical for neuronal excitability. In animal models, loss of NCDN expression disrupts spatial learning and synaptic signaling, underscoring its role in cognitive function. Furthermore, mutations or altered expression of NCDN have been linked to neurodevelopmental disorders and schizophrenia, highlighting its importance in brain health and disease.\u003cbr\u003e\u003cbr\u003eThe NCDN antibody is used to study neuronal signaling and synaptic regulation in both developmental and disease contexts. In research applications, it detects Neurochondrin by western blot, immunocytochemistry, and immunohistochemistry. The antibody identifies distinct cytoplasmic localization in neurons, particularly within dendritic arbors, consistent with its role in synaptic modulation. Beyond the brain, Neurochondrin expression has been detected in cardiac and endocrine tissues, suggesting additional regulatory functions outside the nervous system. Proteomic studies have also linked NCDN to cytoskeletal organization and intracellular trafficking networks.\u003cbr\u003e\u003cbr\u003eThrough its interactions with signaling proteins such as CaMKII and GRM5, Neurochondrin integrates receptor activation with downstream pathways influencing synaptic plasticity and learning. Its modulation of calcium signaling provides a mechanistic link between neurotransmission and neuronal adaptation. Because of these diverse regulatory roles, the NCDN antibody is a valuable reagent for exploring molecular mechanisms underlying cognition, synaptic remodeling, and psychiatric disorders.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=NCDN - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=NCDN - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=NCDN - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/NCDN - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=NCDN+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047296229741,"sku":"FY12675","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_ae97b2b2-6751-4e6b-a2b0-2fa76e67f1c7.jpg?v=1782237047","url":"https:\/\/www.ebiohippo.com\/products\/ncdn-antibody-neurochondrin-bha17135578","provider":"BioHippo","version":"1.0","type":"link"}