{"product_id":"nci-h157-cell-bhc11101140","title":"NCI-H157 cell","description":"NCI-H157 is a human non-small cell lung carcinoma (NSCLC) cell line, primarily used in cancer research to study tumorigenesis, chemotherapy resistance, and the molecular pathways involved in lung cancer progression. NCI-H157 cells are particularly useful for investigating the role of hypoxia-inducible factor-1 alpha (HIF-1α) in NSCLC. Studies have shown that HIF-1α plays a crucial role in promoting angiogenesis, proliferation, and survival of cancer cells under hypoxic conditions. Downregulation of HIF-1α via siRNA in NCI-H157 cells significantly reduces cell proliferation, induces apoptosis, and impairs the invasive ability of the tumor cells.\nMoreover, combination treatments using HIF-1α siRNA and chemotherapy agents, such as cisplatin (DDP), enhance the cytotoxic effects on NCI-H157 cells. The reduction of HIF-1α expression has been shown to increase the activity of apoptotic proteins like caspases 3 and 9 while decreasing the levels of anti-apoptotic proteins such as Bcl-2. Additionally, HIF-1α knockdown inhibits key signaling pathways involved in tumor growth, including the PI3K\/AKT and Raf\/MEK\/ERK pathways. These molecular alterations contribute to the suppression of tumor cell survival and invasiveness.\nThe NCI-H157 cell line is also responsive to various natural compounds and plant extracts. For example, extracts from *Stellera chamaejasme* L. have been found to induce apoptosis in NCI-H157 cells through the Fas death receptor pathway, further emphasizing the cell line's utility in evaluating novel therapeutic agents for lung cancer.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101140\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950218277229,"sku":"300387","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/NCI-H157_20CM1_20Y2678T7_20WaKo_20P1_2020x01_20070225_ch00_1920x1920_d947f3cf-3d5e-4bbe-ba2b-7c01b6d29a56.jpg?v=1769069164","url":"https:\/\/www.ebiohippo.com\/products\/nci-h157-cell-bhc11101140","provider":"BioHippo","version":"1.0","type":"link"}