{"product_id":"nci-h322-cell-bhc11101699","title":"NCI-H322 cell","description":"NCI-H322 is a human non-small cell lung cancer (NSCLC) cell line derived from an adult patient with a bronchioalveolar carcinoma, a histologic subtype of adenocarcinoma. This cell line was established by the NCI-Navy Medical Oncology Branch as part of a comprehensive effort to generate clinically annotated lung cancer models for research and therapeutic development. NCI-H322 exhibits adherent epithelial morphology in vitro and is typically maintained in RPMI-1640 medium supplemented with 10% fetal bovine serum under standard cell culture conditions.\n\nMolecular profiling of NCI-H322 reveals that it carries a KRAS mutation, which contributes to oncogenic signaling through the MAPK\/ERK and PI3K\/AKT pathways. This mutation renders the cell line resistant to EGFR-targeted therapies and makes it suitable for studies focused on KRAS-driven lung adenocarcinoma. Additionally, the line is wild-type for EGFR and TP53, offering a defined genetic context for dissecting KRAS-dependent tumor biology. Its transcriptional and proteomic data have been included in large-scale datasets such as the Cancer Cell Line Encyclopedia (CCLE), where it has contributed to analyses of lineage-specific vulnerabilities and drug response patterns.\n\nNCI-H322 has been used extensively in pharmacologic screening and mechanistic studies to explore sensitivity to MEK inhibitors, PI3K pathway inhibitors, and chemotherapeutic agents. Its consistent performance across studies and well-documented mutation profile make it a valuable preclinical model for KRAS-mutant NSCLC, as well as a key reference in efforts to understand tumor heterogeneity and drug resistance in lung adenocarcinoma.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101699\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950219063661,"sku":"305839","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/NCI-H322_20WaKo_20DAY1_20P1_2020X01_20081025_Overlay_1920x1920_fe48ddb1-d1be-4c67-a0aa-81c228a9c4d6.png?v=1769069172","url":"https:\/\/www.ebiohippo.com\/products\/nci-h322-cell-bhc11101699","provider":"BioHippo","version":"1.0","type":"link"}