{"product_id":"ncor1-antibody-nuclear-receptor-corepressor-1-bha17135841","title":"NCOR1 Antibody \/ Nuclear receptor corepressor 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eNCOR1 Antibody \/ Nuclear receptor corepressor 1 is a anti-NCOR1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human. Reported localization: Nuclear.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NCOR1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC\/IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eNCOR1 antibody detects Nuclear receptor corepressor 1, a transcriptional regulator that mediates repression of gene expression by nuclear hormone receptors and other transcription factors. The UniProt recommended name is Nuclear receptor corepressor 1 (NCOR1), with alternate names including nuclear receptor co-repressor, thyroid hormone receptor-interacting protein 13 (TRAC13), and retinoic acid receptor-binding protein. NCOR1 functions as a scaffold protein that bridges transcription factors with histone deacetylases (HDACs), leading to chromatin condensation and transcriptional silencing.\u003cbr\u003e\u003cbr\u003eFunctionally, NCOR1 antibody recognizes a large nuclear protein (~270 kDa) that forms complexes with histone deacetylase 3 (HDAC3) and transducin beta-like proteins (TBL1X, TBL1XR1), serving as the catalytic core of the NCOR\/SMRT repression complex. NCOR1 regulates gene networks responsive to thyroid hormone, retinoic acid, glucocorticoids, and other ligands by recruiting HDAC3 to promoter regions. Through its receptor-interacting domains, NCOR1 binds unliganded nuclear receptors such as TR, RAR, and RXR to maintain basal transcriptional repression. Upon ligand binding, corepressors are released, and coactivators are recruited to enable gene activation.\u003cbr\u003e\u003cbr\u003eIn developmental and metabolic regulation, NCOR1 influences adipogenesis, gluconeogenesis, circadian rhythm, and immune cell differentiation. Deletion of NCOR1 in adipose tissue leads to increased mitochondrial activity and energy expenditure, highlighting its role in metabolic homeostasis. In neurons, NCOR1 modulates synaptic plasticity and behavior by repressing neural gene programs. Overexpression or mutation of NCOR1 can disrupt transcriptional balance and contribute to diseases including cancer, metabolic syndrome, and neurodevelopmental disorders. For example, NCOR1 loss correlates with enhanced oncogenic signaling in breast and prostate cancer models.\u003cbr\u003e\u003cbr\u003eStructurally, NCOR1 contains multiple repression domains, nuclear receptor interaction motifs (L\/IxxI\/VI), and coiled-coil regions that enable interaction with HDAC3 and transcription factors. The NCOR1 antibody is widely used in chromatin immunoprecipitation (ChIP), western blotting, and immunofluorescence assays to examine chromatin binding, nuclear localization, and HDAC recruitment. The NCOR1 gene is located on chromosome 17p12 and encodes a 2453-amino acid protein conserved across mammals. It shares functional similarity with NCOR2 (SMRT), though the two exhibit distinct expression profiles and complex-specific functions.\u003cbr\u003e\u003cbr\u003eBy targeting a master regulator of transcriptional repression, NCOR1 antibody supports research in gene regulation, epigenetics, and signal-dependent chromatin remodeling.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=NCOR1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=NCOR1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=NCOR1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/NCOR1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=NCOR1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047307534701,"sku":"FY12939","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_9f1e482f-1174-4a86-a4ca-a716a518f03f.jpg?v=1782237062","url":"https:\/\/www.ebiohippo.com\/products\/ncor1-antibody-nuclear-receptor-corepressor-1-bha17135841","provider":"BioHippo","version":"1.0","type":"link"}