{"product_id":"ncor2-antibody-nuclear-receptor-corepressor-2-bha17135285","title":"NCOR2 Antibody \/ Nuclear receptor corepressor 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eNCOR2 Antibody \/ Nuclear receptor corepressor 2 is a anti-NCOR2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as ELISA, Flow cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Western blot (WB) with listed reactivity in Human. Reported localization: Nuclear.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NCOR2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e ELISA, FACS, IF, IHC, ICC, WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eThe NCOR2 antibody targets Nuclear receptor corepressor 2, a transcriptional regulator encoded by the NCOR2 gene. Also known as silencing mediator for retinoid and thyroid hormone receptors (SMRT), this large nuclear protein functions as a scaffold that recruits histone deacetylases (HDACs) and other chromatin-modifying enzymes to suppress gene transcription. Nuclear receptor corepressor 2 interacts with unliganded nuclear hormone receptors, transcription factors, and coregulator complexes to fine-tune gene expression across diverse physiological systems. The NCOR2 antibody allows researchers to explore this protein's roles in transcriptional repression, cell differentiation, and metabolic control.\u003cbr\u003e\u003cbr\u003eNuclear receptor corepressor 2 contains multiple repression domains, nuclear receptor�interaction motifs, and regions that bind HDAC3. By forming multiprotein complexes, NCOR2 promotes chromatin condensation and transcriptional silencing through histone deacetylation. The NCOR2 antibody enables visualization of this protein in nuclear extracts and tissue samples, supporting studies that examine gene regulation by thyroid hormone, retinoic acid, glucocorticoid, and estrogen receptors. Through these interactions, NCOR2 modulates key pathways governing metabolism, development, and circadian rhythm.\u003cbr\u003e\u003cbr\u003eMutations or altered expression of NCOR2 disrupt hormonal and metabolic balance, contributing to endocrine and developmental disorders. In addition, aberrant nuclear receptor corepressor 2 function has been linked to oncogenesis, particularly in breast and prostate cancers, where loss of repression leads to hormone-independent growth. The NCOR2 antibody is used to assess expression levels and nuclear localization patterns, helping identify correlations between corepressor dysfunction and tumor progression. By supporting detection of NCOR2 in cancer tissues, this antibody aids in understanding transcriptional misregulation associated with tumorigenesis.\u003cbr\u003e\u003cbr\u003eBeyond hormone receptor signaling, NCOR2 coordinates repression of inflammatory and immune genes by interacting with transcription factors such as NF-?B and STATs. It participates in maintaining immune tolerance and suppressing chronic inflammation. The NCOR2 antibody enables functional studies into these processes, revealing how corepressor complexes shape immune gene expression. In the central nervous system, NCOR2 also influences neuronal differentiation and synaptic plasticity, underscoring its role as a global regulator of chromatin dynamics.\u003cbr\u003e\u003cbr\u003eThe NCOR2 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry, exhibiting strong nuclear staining consistent with its role as a transcriptional corepressor.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=NCOR2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=NCOR2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=NCOR2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/NCOR2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=NCOR2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047288234349,"sku":"FY12382","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_4a9c6064-2316-4d90-a4ca-2a576a68d059.jpg?v=1782237006","url":"https:\/\/www.ebiohippo.com\/products\/ncor2-antibody-nuclear-receptor-corepressor-2-bha17135285","provider":"BioHippo","version":"1.0","type":"link"}