{"product_id":"ncr3lg1-antibody-b7-h6-natural-cytotoxicity-triggering-receptor-3-ligand-1-bha17135292","title":"NCR3LG1 Antibody \/ B7-H6 \/ Natural cytotoxicity triggering receptor 3 ligand 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eNCR3LG1 Antibody \/ B7-H6 \/ Natural cytotoxicity triggering receptor 3 ligand 1 is a anti-NCR3LG1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cell membrane.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NCR3LG1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eThe NCR3LG1 antibody targets Natural cytotoxicity triggering receptor 3 ligand 1, a cell surface glycoprotein encoded by the NCR3LG1 gene. Also known as B7H6, this protein serves as a ligand for the activating receptor NKp30 (NCR3) expressed on natural killer (NK) cells. The interaction between B7H6 and NKp30 initiates NK cell activation, cytokine release, and cytotoxic responses against tumor and infected cells. The NCR3LG1 antibody provides a vital tool for studying innate immune surveillance and tumor immunology.\u003cbr\u003e\u003cbr\u003eNatural cytotoxicity triggering receptor 3 ligand 1 is a type I transmembrane protein belonging to the B7 family of immune regulatory molecules. It is normally absent from healthy tissues but is induced by cellular stress, transformation, or infection. The NCR3LG1 antibody enables researchers to detect B7H6 expression on tumor cells, identifying targets for immune recognition and clearance. Because it acts as a danger signal for NK cell activation, B7H6 is a focus of research in cancer immunotherapy and immune checkpoint modulation.\u003cbr\u003e\u003cbr\u003eExpression of B7H6 has been reported in various tumors, including leukemia, lymphoma, melanoma, and carcinomas of the lung and ovary. The NCR3LG1 antibody supports studies that examine the relationship between B7H6 expression and tumor immune evasion. Tumor cells may shed soluble B7H6 into the extracellular environment, impairing NK cell function. Detection using the NCR3LG1 antibody allows quantification of both membrane-bound and soluble forms, offering insights into immune escape mechanisms and therapeutic targeting opportunities.\u003cbr\u003e\u003cbr\u003eIn the context of infection, Natural cytotoxicity triggering receptor 3 ligand 1 acts as a stress-induced molecule upregulated by viral or bacterial pathogens, promoting immune activation. The NCR3LG1 antibody supports investigation of these innate immune responses, clarifying how NKp30�B7H6 interactions contribute to early pathogen clearance. Additionally, the ligand's selective expression profile makes it an attractive target for engineered NK cell or bispecific antibody therapies designed to enhance antitumor immunity.\u003cbr\u003e\u003cbr\u003eThe NCR3LG1 antibody is validated for flow cytometry, immunofluorescence, and western blotting, producing distinct membrane staining in positive cell lines.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=NCR3LG1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=NCR3LG1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=NCR3LG1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/NCR3LG1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=NCR3LG1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047285645677,"sku":"FY12389","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_1e104e4e-868f-4570-ae39-c0533a7b093f.jpg?v=1782236995","url":"https:\/\/www.ebiohippo.com\/products\/ncr3lg1-antibody-b7-h6-natural-cytotoxicity-triggering-receptor-3-ligand-1-bha17135292","provider":"BioHippo","version":"1.0","type":"link"}