{"product_id":"ndufs2-antibody-nadh-dehydrogenase-ubiquinone-iron-sulfur-protein-2-bha17135524","title":"NDUFS2 Antibody \/ NADH dehydrogenase ubiquinone iron-sulfur protein 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eNDUFS2 Antibody \/ NADH dehydrogenase ubiquinone iron-sulfur protein 2 is a anti-NDUFS2 Rabbit antibody Recombinant Rabbit Monoclonal clone 30N44 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP) with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NDUFS2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 30N44, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, IP\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eNDUFS2 antibody detects NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, a mitochondrial respiratory chain complex I subunit encoded by the NDUFS2 gene. NDUFS2 is a core catalytic component of complex I, the largest enzyme of the oxidative phosphorylation system. It contains conserved iron-sulfur clusters that mediate electron transfer from NADH to ubiquinone. By supporting this process, NDUFS2 contributes to ATP generation and cellular energy metabolism.\u003cbr\u003e\u003cbr\u003eNDUFS2 antibody is widely applied in mitochondrial biology, bioenergetics, and disease research. Complex I dysfunction is a hallmark of mitochondrial disorders, neurodegeneration, and metabolic disease. Detection of NDUFS2 provides a marker for complex I assembly and activity. By monitoring NDUFS2 expression, researchers can study mechanisms underlying mitochondrial dysfunction in conditions such as Leigh syndrome, Parkinson disease, and ischemia reperfusion injury.\u003cbr\u003e\u003cbr\u003e Western blot assays detect NDUFS2 protein in mitochondrial fractions, while immunohistochemistry highlights expression in metabolically active tissues such as heart, brain, and muscle. Immunofluorescence reveals punctate mitochondrial staining consistent with its inner membrane localization. These applications allow comprehensive analysis of complex I structure and function.\u003cbr\u003e\u003cbr\u003eMutations in NDUFS2 cause severe mitochondrial disease characterized by impaired energy metabolism, developmental delay, and neurodegeneration. By applying NDUFS2 antibody, scientists can investigate the molecular basis of these disorders and evaluate therapeutic strategies aimed at restoring complex I activity.\u003cbr\u003e\u003cbr\u003eBeyond rare genetic disease, NDUFS2 plays roles in hypoxic adaptation, aging, and cancer metabolism. Changes in NDUFS2 expression affect reactive oxygen species production and signaling, linking mitochondrial function to cellular stress responses. The antibody therefore provides a valuable reagent for broad applications in mitochondrial research.\u003cbr\u003e\u003cbr\u003eNDUFS2 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=NDUFS2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=NDUFS2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=NDUFS2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/NDUFS2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=NDUFS2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047294460269,"sku":"FY12621","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_cc907035-9fdb-4ea9-b113-f15e31bca02c.jpg?v=1782237022","url":"https:\/\/www.ebiohippo.com\/products\/ndufs2-antibody-nadh-dehydrogenase-ubiquinone-iron-sulfur-protein-2-bha17135524","provider":"BioHippo","version":"1.0","type":"link"}