{"product_id":"negative-nicotine-ditartrate-bhb21300232","title":"(-)-Nicotine ditartrate","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e (S)-(-)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-ditartrate salt.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 65-31-6\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C18H26N2O12.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;99%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 0.5-200 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Water. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Water. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e nAChR\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e (-)-Nicotine ditartrate activates α7 nAChR with EC50 ~25 µM1.\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eThe nAChR complex, a cholinergic receptor, is composed of five subunits and is found in both the peripheral and central nervous systems. In the mammalian brain, there are as many as nine α subunits (α2 to α10) and three β subunits (β2 to β4). The most abundant receptor subtypes in the brains of humans are α4\/β2, α3\/β4, and α71.(-)-Nicotine ditartrate is a potent agonist of AChR. It stimulates autonomic ganglia and skeletal muscle neuromuscular junctions2. (-)-Nicotine ditartrate is a salt of nicotine of pharmaceutical grade and tartaric acid used for preparation of the products for smoking cessation and as an analytical standard3.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"1 g \/ 1","offer_id":53249711210861,"sku":"N-175-1G-1","price":91.0,"currency_code":"USD","in_stock":true},{"title":"10 g \/ 1","offer_id":53311566381421,"sku":"N-175-10G-1","price":167.0,"currency_code":"USD","in_stock":true},{"title":"25 g \/ 1","offer_id":53311566414189,"sku":"N-175-25G-1","price":223.0,"currency_code":"USD","in_stock":true},{"title":"5 g \/ 1","offer_id":53311566446957,"sku":"N-175-5G-1","price":129.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/N-175_gr.gif?v=1778544439","url":"https:\/\/www.ebiohippo.com\/products\/negative-nicotine-ditartrate-bhb21300232","provider":"BioHippo","version":"1.0","type":"link"}