{"product_id":"neurogenin-1-antibody-neurog1-bha17136346","title":"Neurogenin 1 Antibody \/ NEUROG1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eNeurogenin 1 Antibody \/ NEUROG1 is a anti-NEUROG1 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB), IHC-P, ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Nuclear.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NEUROG1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC-P, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eNEUROG1 (Neurogenin 1) is a basic helix-loop-helix (bHLH) transcription factor that plays a key role in neurogenesis. It functions as a proneural gene, promoting the differentiation of neural progenitor cells into neurons by activating downstream transcriptional programs. NEUROG1 is expressed during early development in regions of the central and peripheral nervous systems where it contributes to neuronal specification and lineage determination. A NEUROG1 antibody is widely used to study developmental neurobiology and transcriptional regulation in neural tissues.    \u003cbr\u003e\u003cbr\u003e  As a member of the neurogenin family, NEUROG1 influences the balance between proliferation and differentiation of progenitor cells. It activates pro-neural genes while repressing alternate cell fates, thereby guiding stem cells toward a neuronal identity. In addition, NEUROG1 interacts with other transcription factors and signaling pathways, including Notch signaling, to ensure precise control of neuronal patterning. Using a NEUROG1 antibody allows researchers to monitor expression patterns and regulatory interactions in neural tissue and stem cell models.    \u003cbr\u003e\u003cbr\u003e  Dysregulation of NEUROG1 has been associated with impaired neural development and has implications for neurodevelopmental disorders. Its expression is also studied in cancer biology, particularly in tumors of neural origin, where abnormal transcription factor activity may contribute to tumorigenesis. Employing a NEUROG1 antibody provides a reliable tool to study its role in both normal development and disease-related contexts.    \u003cbr\u003e\u003cbr\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=NEUROG1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=NEUROG1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=NEUROG1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/NEUROG1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=NEUROG1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047326114157,"sku":"RQ8928","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_8ef22e8e-d312-4987-8dd3-3ff626eae73b.jpg?v=1772019448","url":"https:\/\/www.ebiohippo.com\/products\/neurogenin-1-antibody-neurog1-bha17136346","provider":"BioHippo","version":"1.0","type":"link"}