{"product_id":"nkd1-antibody-naked-cuticle-1-bha17135885","title":"NKD1 Antibody \/ Naked cuticle 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eNKD1 Antibody \/ Naked cuticle 1 is a anti-NKD1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NKD1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eNKD1 antibody detects Naked cuticle homolog 1, a cytoplasmic protein that negatively regulates Wnt signaling by antagonizing Dishevelled-mediated pathway activation. The UniProt recommended name is Naked cuticle homolog 1 (NKD1). This protein acts as a feedback inhibitor within the canonical Wnt\/Beta-catenin signaling cascade, ensuring controlled gene transcription during embryogenesis, cell proliferation, and tissue differentiation.\u003cbr\u003e\u003cbr\u003eFunctionally, NKD1 antibody identifies a 471-amino-acid protein localized in the cytoplasm that binds to Dishevelled (DVL) proteins, sequestering them away from the plasma membrane and preventing downstream beta-catenin stabilization. By limiting beta-catenin nuclear translocation, NKD1 represses Wnt target gene expression, balancing cell fate decisions and tissue patterning. NKD1 expression itself is induced by Wnt signaling, creating a negative feedback loop essential for maintaining signaling homeostasis.\u003cbr\u003e\u003cbr\u003eThe NKD1 gene is located on chromosome 16q12.1 and encodes a conserved protein containing an EF-hand-like calcium-binding motif and a Dishevelled-binding region. It functions in developmental processes such as neural tube formation, axis specification, and organogenesis. In adult tissues, NKD1 continues to modulate Wnt activity to maintain epithelial integrity and stem cell renewal. Loss or silencing of NKD1 leads to excessive Wnt pathway activation, contributing to oncogenesis and abnormal cell proliferation.\u003cbr\u003e\u003cbr\u003eIn cancer research, NKD1 acts as a tumor suppressor. Reduced NKD1 expression has been observed in colorectal, gastric, and hepatocellular carcinomas, where Wnt hyperactivation drives tumor progression. Restoration of NKD1 expression inhibits beta-catenin accumulation and reduces metastatic potential, highlighting its role as a critical checkpoint in Wnt pathway regulation. Beyond oncology, NKD1 also influences bone formation, neurogenesis, and intestinal regeneration through its modulation of Wnt and planar cell polarity signaling.\u003cbr\u003e\u003cbr\u003eNKD1 antibody is widely used in developmental biology, oncology, and cell signaling research. It is suitable for immunoblotting, immunofluorescence, and co-immunoprecipitation to investigate NKD1 expression, localization, and interaction with Wnt signaling components. Detection of NKD1 provides insight into Wnt feedback regulation and its implications in stem cell biology and cancer. In tissue models, NKD1 serves as a molecular marker for Wnt pathway inhibition and differentiation status.\u003cbr\u003e\u003cbr\u003eStructurally, NKD1 contains conserved motifs that enable direct binding to DVL proteins and membranes enriched in phosphatidylinositol phosphates. Its function is regulated by phosphorylation and intracellular calcium levels.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=NKD1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=NKD1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=NKD1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/NKD1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=NKD1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047307895149,"sku":"FY12983","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_b11555d8-87b3-4334-a5a0-2d8c8f256f32.jpg?v=1782237098","url":"https:\/\/www.ebiohippo.com\/products\/nkd1-antibody-naked-cuticle-1-bha17135885","provider":"BioHippo","version":"1.0","type":"link"}