{"product_id":"nlrp2-antibody-nalp2-bha17135637","title":"NLRP2 Antibody \/ NALP2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eNLRP2 Antibody \/ NALP2 is a anti-NLRP2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as ELISA, Flow cytometry (FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC), Western blot (WB) with listed reactivity in Human. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NLRP2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e ELISA, FACS, IP, IF, ICC, WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eNLRP2 antibody detects NACHT, LRR, and PYD domains-containing protein 2, an intracellular innate immune sensor that regulates inflammasome signaling, apoptosis, and embryonic development. Encoded by the NLRP2 gene on chromosome 19q13.42, this protein belongs to the NOD-like receptor (NLR) family characterized by an N-terminal pyrin domain (PYD), a central NACHT domain responsible for oligomerization, and C-terminal leucine-rich repeats (LRRs) involved in ligand sensing. NLRP2 acts as a cytoplasmic pattern-recognition receptor that modulates NF-kB and caspase-1 activation pathways, thereby influencing inflammatory cytokine production.\u003cbr\u003e\u003cbr\u003eNLRP2 expression is found in oocytes, testis, brain, and immune tissues. In germ cells and early embryos, NLRP2 contributes to epigenetic regulation of imprinted gene expression and maintenance of zygotic genome integrity. Mutations in NLRP2 are associated with imprinting disorders such as Beckwith-Wiedemann and multilocus imprinting disturbances. In immune cells, NLRP2 serves as a negative regulator of inflammasome activity, limiting excessive IL-1beta secretion and preventing aberrant inflammation. Its dual role in reproduction and immunity underscores its importance in maintaining both developmental and immune homeostasis.\u003cbr\u003e\u003cbr\u003eThe NLRP2 antibody is used in immunology, developmental, and reproductive research to study inflammasome signaling and maternal effect gene function. Western blot analysis reveals a 115 kilodalton band, while immunofluorescence shows cytoplasmic and perinuclear staining consistent with inflammasome localization. The antibody helps characterize NLRP2's interactions with ASC and caspase-1 in immune signaling complexes. In reproductive studies, it assists in analyzing NLRP2's role in zygotic reprogramming and early embryonic gene activation. Loss or mutation of NLRP2 disrupts normal embryogenesis and can cause early developmental arrest.\u003cbr\u003e\u003cbr\u003eIn addition to its developmental and immunological roles, NLRP2 may contribute to cancer and neurological disease by modulating inflammation and apoptosis. Reduced expression is observed in gliomas and certain carcinomas, while overactivation of inflammasome signaling has been linked to neuroinflammation and tissue injury. The NLRP2 antibody thus supports research across multiple fields, from innate immunity to epigenetic regulation.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=NLRP2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=NLRP2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=NLRP2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/NLRP2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=NLRP2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047297966445,"sku":"FY12734","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_2cdc27cb-d3f5-43a6-878d-657fffecb084.jpg?v=1782237031","url":"https:\/\/www.ebiohippo.com\/products\/nlrp2-antibody-nalp2-bha17135637","provider":"BioHippo","version":"1.0","type":"link"}