{"product_id":"nptx2-antibody-neuronal-pentraxin-2-bha17135432","title":"NPTX2 Antibody \/ Neuronal pentraxin 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eNPTX2 Antibody \/ Neuronal pentraxin 2 is a anti-NPTX2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NPTX2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eNPTX2 antibody detects Neuronal pentraxin-2, a secreted neuronal glycoprotein involved in synaptic plasticity, excitatory synapse formation, and long-term neuronal communication. NPTX2 belongs to the neuronal pentraxin family, which includes NPTX1 and NPTR, proteins that share structural similarities with classical acute-phase pentraxins but function primarily in the central nervous system. The NPTX2 antibody is widely used to study synapse organization, neuronal activity regulation, and neurodegenerative disorders such as Alzheimer's disease.\u003cbr\u003e\u003cbr\u003eNPTX2 is encoded by the NPTX2 gene located on human chromosome 7q21.3. The protein is approximately 47 kilodaltons and secreted from presynaptic terminals, where it binds AMPA-type glutamate receptors on postsynaptic neurons. This interaction enhances receptor clustering, synaptic strength, and excitatory transmission. NPTX2 is highly expressed in cortical and hippocampal neurons and plays a key role in activity-dependent synaptic refinement during learning and memory.\u003cbr\u003e\u003cbr\u003eThe NPTX2 antibody detects a 47 kilodalton band on western blot. In the brain, NPTX2 is upregulated by neuronal activity and acts in concert with NPTX1 and NPTR to regulate synaptic homeostasis. Disruption of NPTX2 expression leads to impaired long-term potentiation and deficits in learning and behavior. Cerebrospinal fluid levels of NPTX2 have been proposed as a biomarker for early-stage neurodegeneration, with reductions correlating to cognitive decline in Alzheimer's and frontotemporal dementia.\u003cbr\u003e\u003cbr\u003eAt the molecular level, NPTX2 binds to neuronal pentraxin receptor (NPTXR) to form hetero-oligomeric complexes that tether AMPA receptors to the postsynaptic membrane. This complex promotes excitatory synapse stabilization and neurotransmitter signaling efficiency. Dysregulation of this system contributes to excitatory-inhibitory imbalance, a hallmark of several neuropsychiatric and neurodegenerative conditions.\u003cbr\u003e\u003cbr\u003eBeyond the nervous system, NPTX2 expression has been observed in pancreatic islets and endocrine tissues, where it may regulate calcium-dependent secretion.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=NPTX2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=NPTX2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=NPTX2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/NPTX2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=NPTX2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047291445613,"sku":"FY12529","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_00613fb6-8386-4db5-9d14-a3ea64139e08.jpg?v=1782237023","url":"https:\/\/www.ebiohippo.com\/products\/nptx2-antibody-neuronal-pentraxin-2-bha17135432","provider":"BioHippo","version":"1.0","type":"link"}