{"product_id":"npy2r-antibody-neuropeptide-y-receptor-type-2-bha17135749","title":"NPY2R Antibody \/ Neuropeptide Y receptor type 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eNPY2R Antibody \/ Neuropeptide Y receptor type 2 is a anti-NPY2R Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NPY2R\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC\/IF, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eNPY2R antibody detects Neuropeptide Y receptor type 2, a G protein-coupled receptor (GPCR) that mediates the effects of neuropeptide Y (NPY) and peptide YY (PYY) in regulating appetite, energy balance, and vascular tone. Encoded by the NPY2R gene on chromosome 4q31.3, this receptor belongs to the rhodopsin-like GPCR family and signals primarily through Gi\/o proteins to inhibit adenylyl cyclase, reduce cyclic AMP production, and modulate calcium and potassium channel activity.\u003cbr\u003e\u003cbr\u003eNPY2R is expressed in the central and peripheral nervous systems, particularly in hypothalamic nuclei involved in appetite control, as well as in adipose tissue, gastrointestinal tract, and cardiovascular system. Activation of NPY2R contributes to satiety signaling, vasoconstriction, and neuroendocrine secretion regulation. In neurons, NPY2R often acts as an autoreceptor, controlling presynaptic release of NPY and other neurotransmitters, thus fine-tuning synaptic transmission and energy homeostasis.\u003cbr\u003e\u003cbr\u003eThe NPY2R antibody is widely used in neuroscience, endocrinology, and metabolism research to investigate neuropeptide signaling, feeding behavior, and receptor pharmacology. Western blot analysis identifies a 43 kilodalton band corresponding to NPY2R, while immunohistochemistry reveals membrane-associated staining in hypothalamic neurons and vascular smooth muscle cells. This antibody supports studies examining receptor localization, ligand binding, and downstream signaling in physiological and pathological contexts.\u003cbr\u003e\u003cbr\u003eAt the molecular level, NPY2R activation influences pathways such as ERK1\/2 and PI3K\/AKT, affecting neuronal excitability and metabolic regulation. Altered NPY2R expression or function is linked to obesity, anxiety, hypertension, and gastrointestinal disorders. Pharmacological targeting of NPY2R offers therapeutic potential for appetite control and cardiovascular modulation. The NPY2R antibody provides a valuable tool for mapping receptor distribution and characterizing its role in neuroendocrine and metabolic signaling.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=NPY2R - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=NPY2R - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=NPY2R - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/NPY2R - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=NPY2R+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047303504237,"sku":"FY12847","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_f52b9bdf-dcdf-44ca-adc4-49ded1ff84b7.jpg?v=1782237051","url":"https:\/\/www.ebiohippo.com\/products\/npy2r-antibody-neuropeptide-y-receptor-type-2-bha17135749","provider":"BioHippo","version":"1.0","type":"link"}