{"product_id":"nr2c2-antibody-nuclear-receptor-subfamily-2-group-c-member-2-tr4-bha17135555","title":"NR2C2 Antibody \/ Nuclear receptor subfamily 2 group C member 2 \/ TR4","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eNR2C2 Antibody \/ Nuclear receptor subfamily 2 group C member 2 \/ TR4 is a anti-NR2C2 Rabbit antibody Recombinant Rabbit Monoclonal clone 31N37 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NR2C2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 31N37, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eNR2C2 antibody detects nuclear receptor subfamily 2 group C member 2, a transcription factor encoded by the NR2C2 gene. NR2C2 belongs to the nuclear receptor superfamily and is also known as Testicular receptor 4 (TR4). It binds specific DNA response elements and regulates genes involved in metabolism, differentiation, and development. NR2C2 functions as both an activator and repressor, depending on cellular context and cofactors, and plays key roles in the endocrine system, reproductive biology, and brain function.\u003cbr\u003e\u003cbr\u003eNR2C2 antibody is widely applied in endocrinology, neuroscience, and cancer research. In reproductive tissues, NR2C2 regulates steroidogenesis and germ cell development. In the central nervous system, it contributes to neuronal differentiation and brain development. Altered NR2C2 expression has been linked to prostate cancer, glioma, and developmental disorders. By detecting NR2C2, researchers can investigate how nuclear receptors integrate hormonal signals with transcriptional control across diverse tissues.\u003cbr\u003e\u003cbr\u003e Western blot assays detect NR2C2 protein bands in nuclear fractions, while immunohistochemistry highlights expression in reproductive and neural tissues. Immunofluorescence maps NR2C2 localization to the nucleus, consistent with its role as a DNA binding transcription factor. These applications make NR2C2 antibody versatile for research into nuclear receptor biology.\u003cbr\u003e\u003cbr\u003eNR2C2 interacts with corepressors, coactivators, and chromatin remodeling complexes, positioning it as a hub in transcriptional networks. It regulates genes controlling lipid metabolism, energy balance, and differentiation. By applying NR2C2 antibody, scientists can evaluate how transcriptional circuits controlled by nuclear receptors contribute to health and disease.\u003cbr\u003e\u003cbr\u003eNR2C2 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=NR2C2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=NR2C2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=NR2C2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/NR2C2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=NR2C2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047296360813,"sku":"FY12652","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_b84f35ff-a2fa-4b01-9e0d-43d22be10ec2.jpg?v=1772019322","url":"https:\/\/www.ebiohippo.com\/products\/nr2c2-antibody-nuclear-receptor-subfamily-2-group-c-member-2-tr4-bha17135555","provider":"BioHippo","version":"1.0","type":"link"}