{"product_id":"nrcam-antibody-neuronal-cell-adhesion-molecule-bha17136367","title":"NRCAM Antibody \/ Neuronal cell adhesion molecule","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eNRCAM Antibody \/ Neuronal cell adhesion molecule is a anti-NRCAM Rabbit antibody Recombinant Rabbit Monoclonal clone ACOH-14 supplied in Purified format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NRCAM\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone ACOH-14, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eNRCAM antibody is a valuable reagent for studying neural development, cell adhesion, and axonal guidance. The encoded protein, neuronal cell adhesion molecule (NRCAM), is a member of the immunoglobulin superfamily of cell adhesion molecules. NRCAM is primarily expressed in the nervous system, where it mediates interactions between neurons and glial cells. By promoting cell-cell adhesion, axon pathfinding, and synapse formation, NRCAM plays a fundamental role in establishing and maintaining neural circuits.\u003cbr\u003e\u003cbr\u003eDuring development, NRCAM contributes to neurite outgrowth and guidance by interacting with other adhesion molecules, extracellular matrix proteins, and cytoskeletal regulators. It facilitates the migration of neurons and the fasciculation of axons, ensuring proper connectivity in the developing brain and spinal cord. In mature neurons, NRCAM continues to support synaptic plasticity and neuronal communication, making it critical for both development and functional maintenance of the nervous system.\u003cbr\u003e\u003cbr\u003eResearch has linked NRCAM to multiple human diseases. Genetic studies suggest associations with autism spectrum disorders, schizophrenia, and attention deficit hyperactivity disorder, where altered cell adhesion and synaptic signaling may contribute to pathogenesis. NRCAM expression has also been implicated in cancer biology, particularly in melanoma and neuroblastoma, where it may promote tumor cell adhesion, migration, and metastasis. These findings highlight NRCAM as a multifunctional protein relevant to both neuroscience and oncology.\u003cbr\u003e\u003cbr\u003eAt the molecular level, neuronal cell adhesion molecule contains six immunoglobulin-like domains and five fibronectin type III repeats, followed by a single transmembrane region and a cytoplasmic tail. This structure enables NRCAM to form homophilic and heterophilic interactions that regulate adhesion and signaling. Through links to the actin cytoskeleton and intracellular kinases, NRCAM modulates cellular morphology, motility, and signaling responses.\u003cbr\u003e\u003cbr\u003eThe NRCAM antibody is widely used in western blotting, immunohistochemistry, immunofluorescence, and flow cytometry to detect protein expression and localization. These applications are essential for mapping NRCAM distribution in developing and mature tissues, as well as examining its role in disease states. For researchers focused on neural connectivity, synapse biology, or tumor cell behavior, the NRCAM antibody provides a reliable detection tool.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=NRCAM - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=NRCAM - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=NRCAM - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/NRCAM - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=NRCAM+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047328342381,"sku":"RQ8949","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_20a71a91-440b-438a-ad5e-32aeecbcc25f.jpg?v=1772019448","url":"https:\/\/www.ebiohippo.com\/products\/nrcam-antibody-neuronal-cell-adhesion-molecule-bha17136367","provider":"BioHippo","version":"1.0","type":"link"}