{"product_id":"ns-6180-bhb21300243","title":"NS-6180","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e 4-[[3-(Trifluoromethyl)phenyl]methy­l]-2H-1,4-benzothiazin-3(4H)-one.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 353262-04-1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C16H12F3NOS.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 10 nM - 1 μM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e 100mM DMSO. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e 100mM DMSO. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e KCa3.1 channels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e NS-6180 blocks SK4 channels with IC50 of 9, 14 and 15 nM for rat, human and mouse erythrocyte KCa3.1 channels respectively1.\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eThe benzothiazinone NS-6180 is a potent and selective KCa3.1 channel blocker1.The Ca2+-activated K+ channel, KCa3.1, plays a major role in the controlled expression of essential genes orchestrating proliferation, migration and cytokine production by participating in the regulation of calcium entry. A highly regulated and sustained increase in cytosolic Ca2+ is critical in these processes thus, the KCa3.1 channel is a potential target for therapy of immune disease1.Inhibition of KCa3.1 channel by NS-6180 demonstrates IC50 value of 14 nM in human, 9 nM in rat and 15 nM in mouse. NS6180 also has the ability to inhibit KCa1.1, KV1.3 and KV11.1 channels with IC50s above 10 µM2.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249711047021,"sku":"N-230-10MG-1","price":117.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311568675181,"sku":"N-230-25MG-1","price":262.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311568707949,"sku":"N-230-5MG-1","price":85.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311568740717,"sku":"N-230-50MG-1","price":468.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/N-230_gr.gif?v=1778544439","url":"https:\/\/www.ebiohippo.com\/products\/ns-6180-bhb21300243","provider":"BioHippo","version":"1.0","type":"link"}