{"product_id":"nsc-66811-bhb11900126","title":"NSC-66811","description":"\u003cp\u003eNSC-66811 is a novel small-molecule inhibitor that disrupts the MDM2-p53 interaction, a key regulatory axis in cell cycle control and apoptosis. By mimicking three critical p53 residues, NSC-66811 binds to MDM2 with high affinity (Ki = 120 nM), preventing MDM2-mediated degradation of p53. This leads to stabilization and activation of p53, promoting transcription of downstream genes involved in cell cycle arrest and apoptosis. While primarily studied in oncology, the p53 pathway is increasingly recognized for its role in neurodegenerative diseases, including Alzheimer's and Parkinson's, where dysregulated apoptosis and impaired DNA repair contribute to neuronal loss. NSC-66811 may offer a mechanistic tool to explore p53-mediated neuroprotection and cellular stress responses in neural models.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040944644461,"sku":"SIH-338-10MG","price":148.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53040964272493,"sku":"SIH-338-50MG","price":607.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-338_NSC-66811_Chemical_Structure.png?v=1771837630","url":"https:\/\/www.ebiohippo.com\/products\/nsc-66811-bhb11900126","provider":"BioHippo","version":"1.0","type":"link"}