{"product_id":"ntsr2-antibody-neurotensin-receptor-type-2-bha17136042","title":"NTSR2 Antibody \/ Neurotensin receptor type 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eNTSR2 Antibody \/ Neurotensin receptor type 2 is a anti-NTSR2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NTSR2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eNTSR2 antibody detects Neurotensin receptor type 2, a G protein-coupled receptor (GPCR) that mediates the effects of the neuropeptide neurotensin on neuronal activity, pain modulation, and inflammation. The UniProt recommended name is Neurotensin receptor type 2 (NTSR2). This receptor couples to G proteins to trigger intracellular calcium mobilization and MAPK pathway activation in response to neurotensin binding.\u003cbr\u003e\u003cbr\u003eFunctionally, NTSR2 antibody identifies a 410-amino-acid seven-transmembrane receptor localized primarily in the central nervous system and peripheral tissues. NTSR2 regulates dopaminergic signaling, nociception, and gastrointestinal motility. It is distinct from NTSR1 in its lower affinity for neurotensin and its unique coupling to Gq and Gi proteins, leading to both excitatory and inhibitory cellular effects.\u003cbr\u003e\u003cbr\u003eThe NTSR2 gene is located on chromosome 2p25.1 and is highly expressed in the brainstem, hypothalamus, and spinal cord. Peripheral expression in immune cells and smooth muscle contributes to neuroimmune and cardiovascular regulation. NTSR2 activation influences neurotransmitter release, stress response, and vascular tone.\u003cbr\u003e\u003cbr\u003ePathologically, dysregulation of NTSR2 signaling has been associated with pain disorders, schizophrenia, addiction, and cancer progression. Its activation promotes cell migration and survival in certain tumors. Research using NTSR2 antibody supports studies in neuroscience, signal transduction, and receptor pharmacology.\u003cbr\u003e\u003cbr\u003eNTSR2 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect GPCRs and neuropeptide receptors. \u003cbr\u003e\u003cbr\u003eStructurally, Neurotensin receptor type 2 features seven transmembrane helices typical of GPCRs, an extracellular ligand-binding region, and an intracellular tail that interacts with G proteins and arrestins. This antibody enables investigation of NTSR2's regulatory role in neurotransmission and cellular signaling.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=NTSR2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=NTSR2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=NTSR2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/NTSR2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=NTSR2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047313432941,"sku":"FY13140","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_5de797c8-d837-481b-ad91-f22fe2086d76.jpg?v=1782237089","url":"https:\/\/www.ebiohippo.com\/products\/ntsr2-antibody-neurotensin-receptor-type-2-bha17136042","provider":"BioHippo","version":"1.0","type":"link"}