{"product_id":"nup107-antibody-nucleoporin-107-bha17135819","title":"NUP107 Antibody \/ Nucleoporin 107","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eNUP107 Antibody \/ Nucleoporin 107 is a anti-NUP107 Rabbit antibody Recombinant Rabbit Monoclonal clone 29N68 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NUP107\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 29N68, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eNUP107 antibody detects Nuclear pore complex protein Nup107, encoded by the NUP107 gene. Nup107 is a core scaffold protein of the nuclear pore complex, the large multiprotein structure that spans the nuclear envelope and mediates nucleocytoplasmic transport. This protein is part of the Nup107 160 subcomplex, which is required for nuclear pore assembly, maintenance, and cell cycle regulated dynamics. NUP107 antibody enables detection of this essential nuclear pore component in studies of transport, nuclear envelope biology, and cell cycle control.\u003cbr\u003e\u003cbr\u003eNuclear pore complex protein Nup107 participates in the bidirectional transport of macromolecules, including mRNA, ribonucleoproteins, and proteins with nuclear localization or export signals. The Nup107 complex acts as a scaffold for pore assembly and contributes to nuclear envelope reformation after mitosis. Research using NUP107 antibody has revealed that disruption of this subunit leads to defective pore assembly, impaired nucleocytoplasmic trafficking, and cell cycle arrest. Its fundamental role in nuclear structure makes it indispensable for normal cell physiology.\u003cbr\u003e\u003cbr\u003eMutations or reduced expression of NUP107 have been linked to human disease, particularly nephrotic syndrome and premature ovarian failure. These conditions arise from defective nuclear pore assembly, underscoring the importance of this protein in development and tissue homeostasis. Studies with NUP107 antibody have also associated its dysfunction with cancers, where altered transport may affect oncogene regulation and DNA repair pathways. By examining Nup107 expression, researchers can better understand how nuclear pore biology intersects with human disease.\u003cbr\u003e\u003cbr\u003eNUP107 antibody is suitable for western blotting, immunofluorescence, and immunohistochemistry. Western blotting reveals protein levels in dividing cells, while immunofluorescence shows localization at the nuclear envelope throughout interphase and redistribution during mitosis. Immunohistochemistry highlights expression in kidney, ovary, and other tissues affected by Nup107 mutations. These applications demonstrate the utility of NUP107 antibody in diverse cell biology and pathology research.\u003cbr\u003e\u003cbr\u003eBy supplying validated NUP107 antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=NUP107 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=NUP107 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=NUP107 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/NUP107 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=NUP107+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047306125677,"sku":"FY12917","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_d097ba1e-9574-4fbb-9ecc-1b0933a12fb0.jpg?v=1772019362","url":"https:\/\/www.ebiohippo.com\/products\/nup107-antibody-nucleoporin-107-bha17135819","provider":"BioHippo","version":"1.0","type":"link"}