{"product_id":"nup155-antibody-nucleoporin-155-bha17135300","title":"NUP155 Antibody \/ Nucleoporin 155","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eNUP155 Antibody \/ Nucleoporin 155 is a anti-NUP155 Rabbit antibody Recombinant Rabbit Monoclonal clone 30N56 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NUP155\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 30N56, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eNUP155 antibody recognizes nucleoporin 155, a major component of the nuclear pore complex encoded by the NUP155 gene. Nuclear pore complexes are large protein assemblies embedded in the nuclear envelope that regulate transport of molecules between the nucleus and cytoplasm. NUP155 contributes to the structural integrity of the pore and facilitates trafficking of RNAs, proteins, and signaling molecules.\u003cbr\u003e\u003cbr\u003eNUP155 antibody is commonly used in studies of nucleocytoplasmic transport and nuclear architecture. The protein is particularly important for maintaining nuclear envelope stability and selective transport of cargo. Defects in NUP155 impair nuclear pore complex assembly and disrupt gene regulation by altering nucleo cytoplasmic communication.\u003cbr\u003e\u003cbr\u003eThe antibody is suitable for western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. In western blot assays, NUP155 antibody recognizes protein bands corresponding to the expected molecular weight. Immunohistochemistry shows localization at the nuclear envelope, while immunofluorescence provides fine resolution of subnuclear distribution. These applications make NUP155 antibody versatile for research in molecular biology and cell signaling.\u003cbr\u003e\u003cbr\u003eClinical research has linked NUP155 mutations to atrial fibrillation and sudden cardiac death. The connection underscores the importance of nuclear pore complexes beyond basic transport, showing that nuclear envelope proteins contribute to cardiac rhythm and function. By detecting NUP155, researchers can explore how mutations or altered expression influence disease progression.\u003cbr\u003e\u003cbr\u003eNucleoporins, including NUP155, are increasingly recognized as regulators of gene expression. Their roles extend to chromatin organization, DNA repair, and signal transduction. Dysregulation of nucleoporins has been linked to cancer and developmental disorders. NUP155 antibody provides a tool to investigate how nuclear pore function impacts diverse biological processes.\u003cbr\u003e\u003cbr\u003eNUP155 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=NUP155 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=NUP155 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=NUP155 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/NUP155 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=NUP155+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047286497645,"sku":"FY12397","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_9a50b86e-7246-4dd1-b33f-0eaaab65b9f7.jpg?v=1772019287","url":"https:\/\/www.ebiohippo.com\/products\/nup155-antibody-nucleoporin-155-bha17135300","provider":"BioHippo","version":"1.0","type":"link"}