{"product_id":"nup160-antibody-nuclear-pore-complex-protein-nup160-bha17135333","title":"NUP160 Antibody \/ Nuclear pore complex protein Nup160","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eNUP160 Antibody \/ Nuclear pore complex protein Nup160 is a anti-NUP160 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Nuclear.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NUP160\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC\/IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eThe NUP160 antibody targets Nuclear pore complex protein Nup160, a large scaffold protein encoded by the NUP160 gene. Nuclear pore complex protein Nup160 is an essential component of the Nup107-160 subcomplex that forms the structural framework of the nuclear pore complex (NPC). This complex regulates bidirectional transport of macromolecules between the nucleus and cytoplasm, controlling RNA export, protein import, and cell-cycle progression. The NUP160 antibody provides researchers with a robust reagent for studying nucleocytoplasmic transport, nuclear envelope assembly, and the architecture of the NPC.\u003cbr\u003e\u003cbr\u003eNuclear pore complex protein Nup160 contributes to the assembly and stability of the Nup107-160 complex, which includes Nup107, Nup133, Nup96, and Sec13. It localizes to both the cytoplasmic and nucleoplasmic faces of the nuclear envelope and interacts with importins, exportins, and Ran GTPase to regulate nuclear transport. The NUP160 antibody enables detection of this scaffold protein in isolated nuclei and cultured cells, revealing how changes in NPC composition affect molecular trafficking.\u003cbr\u003e\u003cbr\u003eBeyond transport, Nuclear pore complex protein Nup160 plays key roles in mitosis. During cell division, the Nup107-160 complex redistributes to kinetochores, where it assists in spindle assembly and chromosome segregation. The NUP160 antibody supports visualization of these dynamic localization patterns, helping clarify the interface between nuclear pore biology and mitotic regulation. Disruption of NUP160 expression or function leads to nuclear envelope defects, delayed cell-cycle progression, and genomic instability.\u003cbr\u003e\u003cbr\u003eMutations in NUP160 have been linked to steroid-resistant nephrotic syndrome and immune dysregulation, reflecting the importance of intact nuclear transport in tissue homeostasis. The NUP160 antibody is used in studies of nuclear pore-related diseases, including autoimmune and neurodegenerative conditions. Reduced expression or structural alteration of Nup160 can also influence viral nuclear import and cellular stress responses.\u003cbr\u003e\u003cbr\u003eThe NUP160 antibody performs effectively in western blotting, immunofluorescence, and immunohistochemistry, yielding strong nuclear envelope staining consistent with pore complex localization.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=NUP160 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=NUP160 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=NUP160 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/NUP160 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=NUP160+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047286104429,"sku":"FY12430","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_9ee3c563-b4cc-42f0-a3e9-593491cedf11.jpg?v=1782236989","url":"https:\/\/www.ebiohippo.com\/products\/nup160-antibody-nuclear-pore-complex-protein-nup160-bha17135333","provider":"BioHippo","version":"1.0","type":"link"}