{"product_id":"nup88-antibody-nuclear-pore-complex-protein-nup88-nucleoporin-88-bha17136025","title":"NUP88 Antibody \/ Nuclear pore complex protein Nup88 \/ Nucleoporin 88","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eNUP88 Antibody \/ Nuclear pore complex protein Nup88 \/ Nucleoporin 88 is a anti-NUP88 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA with listed reactivity in Human. Reported localization: Nuclear.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NUP88\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC, IF, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eNUP88 antibody detects Nuclear pore complex protein Nup88, a structural component of the nuclear pore complex that regulates nucleocytoplasmic transport. The UniProt recommended name is Nuclear pore complex protein Nup88 (NUP88). This protein interacts with other nucleoporins to facilitate the bidirectional exchange of macromolecules between the nucleus and cytoplasm, maintaining cellular communication and homeostasis.\u003cbr\u003e\u003cbr\u003eFunctionally, NUP88 antibody identifies a 741-amino-acid nucleoporin localized to the cytoplasmic face of the nuclear pore complex. NUP88 forms a subcomplex with NUP214 and NUP62 that assists in nuclear export of ribonucleoproteins and protein cargoes. It is also involved in spindle assembly and chromosome segregation during mitosis, highlighting its dual role in transport and cell cycle control.\u003cbr\u003e\u003cbr\u003eThe NUP88 gene is located on chromosome 17p13.1 and is ubiquitously expressed in proliferating cells. Its expression is dynamically regulated during mitosis and stress responses. NUP88�s proper function ensures balanced nucleocytoplasmic transport and mitotic progression, while its mislocalization disrupts nuclear integrity.\u003cbr\u003e\u003cbr\u003ePathologically, overexpression of NUP88 has been linked to several cancers, including breast, colorectal, and hepatocellular carcinoma, where it promotes nuclear transport of oncogenic factors. Mutations in NUP88 cause neuromuscular and developmental disorders such as fetal akinesia deformation sequence. Research using NUP88 antibody supports studies in nuclear transport, mitosis, and tumor biology.\u003cbr\u003e\u003cbr\u003eNUP88 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect nuclear pore complex proteins. \u003cbr\u003e\u003cbr\u003eStructurally, Nuclear pore complex protein Nup88 contains coiled-coil domains that mediate interaction with other nucleoporins and a C-terminal alpha-helical region that anchors it within the nuclear envelope. This antibody aids in analyzing NUP88's role in nuclear transport and mitotic regulation.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=NUP88 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=NUP88 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=NUP88 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/NUP88 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=NUP88+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047313039725,"sku":"FY13123","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_88e4a293-1793-4fd7-971f-a3cbfff39295.jpg?v=1782237090","url":"https:\/\/www.ebiohippo.com\/products\/nup88-antibody-nuclear-pore-complex-protein-nup88-nucleoporin-88-bha17136025","provider":"BioHippo","version":"1.0","type":"link"}