{"product_id":"nur-rxr-reporter-lentivirus-bhv19400234","title":"NUR\/RXR Reporter Lentivirus","description":"\u003cdiv class=\"bhp-desc\"\u003e\n\u003cstyle\u003e.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}.bhp-desc p{margin:0 0 12px}.bhp-desc ul{margin:0 0 12px 22px}.bhp-desc li{margin:0 0 6px}\u003c\/style\u003e\n\u003ch2\u003e\u003cstrong\u003eBackground\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp\u003eThe NUR proteins NUR77 (NR4A1) and NURR1 (NR4A2) are orphan nuclear receptors of the NR4A family that act as early-response transcription factors regulating cell survival, metabolism, and inflammation. NUR receptors can function as monomers, homodimers, or heterodimers with retinoid X receptor (RXR), and in the latter configuration they activate transcription in response to RXR ligands. NUR77 also suppresses inflammatory responses by inhibiting NF-κB signaling, and the NR4A family has been implicated in metabolic regulation and in lung conditions such as asthma, acute lung injury, and pulmonary fibrosis, making the NUR\/RXR axis relevant to metabolic and endocrine research.\u003c\/p\u003e\n\u003ch2\u003e\u003cstrong\u003eProduct Description \u0026amp; Applications\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp\u003eThe NUR\/RXR Reporter Lentivirus is a transcription-factor reporter system for detecting transcriptional activity driven by NUR proteins (NUR77 and NURR1) in heterodimer with RXR. It contains tandem repeats of NUR and RXR DNA-binding half-sites arranged as a DR5 element, coupled to a minimal TATA-box promoter and an upstream enhancer that maximizes signal-to-noise to drive a fluorescent or luminescent reporter (including BFP2, d2GFP, EGFP, GFP, mCherry, RFP, firefly, Gaussia, or Renilla luciferase). A constitutively expressed selection marker (blasticidin, hygromycin, puromycin, or zeocin) supports stable polyclonal cell line generation. Stable lentiviral integration provides consistent reporter expression in dividing and post-mitotic cells, including primary and cryopreserved material, with readout by microscopy, flow cytometry, or luminometry. Supplied as purified lentiviral particles.\u003c\/p\u003e\n\u003ch2\u003e\u003cstrong\u003eAbout This Product\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp\u003eThis reporter lentivirus places a BFP2, d2GFP, EGFP, Firefly Luc, Gaussia Luc, GFP, GFP + Firefly Luc, mCherry, Renilla Luc, RFP, RFP + Firefly Luc reporter gene under the control of tandem consensus response elements specific for the NUR\/RXR transcription factor, coupled to a minimal TATA-box promoter and a proprietary upstream enhancer that maximizes signal-to-noise. The constitutively expressed selection marker (Hygromycin, Zeocin, Puromycin, Blasticidin) and\/or secondary reporter enables stable polyclonal cell line generation and flexible readout by fluorescence microscopy, flow cytometry, or luminometry.\u003c\/p\u003e\n\u003cp\u003eStable integration via the lentiviral backbone ensures consistent, clonally representative reporter expression in dividing and post-mitotic target cells — including primary T cells, macrophages, organoids, and cryopreserved material — eliminating the variability inherent to transient transfection. The self-inactivating LTR design and third-generation packaging minimize insertional mutagenesis risk and ensure biosafety classification at BSL-2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"LipExoGen Biotech","offers":[{"title":"NUR\/RXR-TAG-Puro \/ GFP \/ 5x10^6","offer_id":53251623092589,"sku":"LTV-0127-1S","price":595.0,"currency_code":"USD","in_stock":true},{"title":"Negative Control (NC-TAG-Puro) \/ GFP \/ 5x10^6","offer_id":53362084413805,"sku":"LTV-0127-1N","price":595.0,"currency_code":"USD","in_stock":true},{"title":"Positive Control (PC-TAG-Puro) \/ GFP \/ 5x10^6","offer_id":53362084446573,"sku":"LTV-0127-1P","price":595.0,"currency_code":"USD","in_stock":true},{"title":"NUR\/RXR-TAL-Puro \/ Firefly Luc \/ 2x10^6","offer_id":53362084479341,"sku":"LTV-0127-3S","price":595.0,"currency_code":"USD","in_stock":true},{"title":"Negative Control (NC-TAL-Puro) \/ Firefly Luc \/ 2x10^6","offer_id":53362084512109,"sku":"LTV-0127-3N","price":595.0,"currency_code":"USD","in_stock":true},{"title":"Positive Control (PC-TAL-Puro) \/ Firefly Luc \/ 2x10^6","offer_id":53362084544877,"sku":"LTV-0127-3P","price":595.0,"currency_code":"USD","in_stock":true},{"title":"Internal Control (RLuc-BSD) \/ Renilla Luc \/ 2x10^6","offer_id":53362084577645,"sku":"LTV-0127-3R","price":595.0,"currency_code":"USD","in_stock":true},{"title":"NUR\/RXR-TAR-BSD \/ RFP \/ 5x10^6","offer_id":53362084610413,"sku":"LTV-0127-2S","price":595.0,"currency_code":"USD","in_stock":true},{"title":"NUR\/RXR-TAL-BSD \/ Firefly Luc \/ 2x10^6","offer_id":53362084643181,"sku":"LTV-0127-4S","price":595.0,"currency_code":"USD","in_stock":true},{"title":"NUR\/RXR-TAG-BSD \/ GFP \/ 5x10^6","offer_id":53362084675949,"sku":"LTV-0127-5S","price":595.0,"currency_code":"USD","in_stock":true},{"title":"NUR\/RXR-TAR-Puro \/ RFP \/ 5x10^6","offer_id":53362084708717,"sku":"LTV-0127-6S","price":595.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/NUR-RXR-Reporter-Figure.jpg?v=1776934280","url":"https:\/\/www.ebiohippo.com\/products\/nur-rxr-reporter-lentivirus-bhv19400234","provider":"BioHippo","version":"1.0","type":"link"}