{"product_id":"nusinersen-bhb21900297","title":"Nusinersen","description":"\u003cdiv class=\"bhp-desc\"\u003e\n\u003cstyle\u003e.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}.bhp-desc p{margin:0 0 12px}.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\u003c\/style\u003e\n\u003cspan class=\"bhp-cat-pill\"\u003eBioactive Small Molecules\u003c\/span\u003e\u003ch2\u003eCompound Overview\u003c\/h2\u003e\n\u003cp\u003eNusinersen is an antisense oligonucleotide active molecule that modifies the pre-messenger RNA splicing of the SMN2 gene, thereby promoting production of full-length SMN protein. It improves spinal muscular atrophy\u003csup\u003e[1][2][3]\u003c\/sup\u003e. It is supplied as a white to off-white solid (C234H340N61O128P17S17, MW 7127.19) at 97.56% purity.\u003c\/p\u003e\n\u003ch2\u003ePhysical \u0026amp; Chemical Properties\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eCAS Number\u003c\/th\u003e\n\u003ctd\u003e1258984-36-9\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eMolecular Formula\u003c\/th\u003e\n\u003ctd\u003eC234H340N61O128P17S17\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003e7127.19 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePurity\u003c\/th\u003e\n\u003ctd\u003e97.56%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eAppearance\u003c\/th\u003e\n\u003ctd\u003eSolid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eColor\u003c\/th\u003e\n\u003ctd\u003eWhite to off-white\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSequence\u003c\/th\u003e\n\u003ctd\u003eRNA, [2'-O-(2-methoxyethyl)](P-thio)(m5U-m5C-A-m5C-m5U-m5U-m5U-m5C-A-m5U-A-A-m5U-G-m5C-m5U-G-G)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSMILES\u003c\/th\u003e\n\u003ctd\u003eCOCCO[C@@H]1[C@@H]([C@H](O[C@H]1n2c3c(C(NC(N)=N3)=O)nc2)COP(O)(O[C@@H]4[C@H](O[C@@H](n5c6c(C(NC(N)=N6)=O)nc5)[C@@H]4OCCOC)COP(S)(O[C@@H]7[C@H](O[C@@H](N8C=C(C(NC8=O)=O)C)[C@@H]7OCCOC)COP(O)(O[C@@H]9[C@H](O[C@@H](N%10C=C(C(N)=NC%10=O)C)[C@@H]9OCCOC)COP(O)(O[C@@H]%11[C@H](O[C@@H](n%12c%13c(C(NC(N)=N%13)=O)nc%12)[C@@H]%11OCCOC)COP(O)(O[C@@H]%14[C@H](O[C@@H](N%15C=C(C(NC%15=O)=O)C)[C@@H]%14OCCOC)COP(O)(O[C@@H]%16[C@H](O[C@@H](n(cn%17)c%18c%17c(N)ncn%18)[C@@H]%16OCCOC)COP(O)(O[C@@H]%19[C@H](O[C@@H](n(cn%20)c%21c%20c(N)ncn%21)[C@@H]%19OCCOC)COP(O)(O[C@@H]%22[C@H](O[C@@H](N%23C=C(C(NC%23=O)=O)C)[C@@H]%22OCCOC)COP(O)(O[C@@H]%24[C@H](O[C@@H](n(cn%25)c%26c%25c(N)ncn%26)[C@@H]%24OCCOC)COP(O)(O[C@@H]%27[C@H](O[C@@H](N%28C=C(C(N)=NC%28=O)C)[C@@H]%27OCCOC)COP(O)(O[C@@H]%29[C@H](O[C@@H](N%30C=C(C(NC%30=O)=O)C)[C@@H]%29OCCOC)COP(O)(O[C@@H]%31[C@H](O[C@@H](N%32C=C(C(NC%32=O)=O)C)[C@@H]%31OCCOC)COP(O)(O[C@@H]%33[C@H](O[C@@H](N%34C=C(C(NC%34=O)=O)C)[C@@H]%33OCCOC)COP(O)(O[C@@H]%35[C@H](O[C@@H](N%36C=C(C(N)=NC%36=O)C)[C@@H]%35OCCOC)COP(O)(O[C@@H]%37[C@H](O[C@@H](n(cn%38)c%39c%38c(N)ncn%39)[C@@H]%37OCCOC)COP(O)(O[C@@H]%40[C@H](O[C@@H](N%41C=C(C(N)=NC%41=O)C)[C@@H]%40OCCOC)COP(O)(O[C@@H]%42[C@H](O[C@@H](N%43C=C(C(NC%43=O)=O)C)[C@@H]%42OCCOC)CO)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=O)=S)O\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSignaling Pathway\u003c\/th\u003e\n\u003ctd\u003eCell Cycle\/DNA Damage\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003e-20°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eShipping\u003c\/th\u003e\n\u003ctd\u003eRoom temperature in continental US; may vary elsewhere.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003ch2\u003eLiterature Cited\u003c\/h2\u003e\n\u003cp style=\"font-size:14px;color:#555;margin:0 0 10px\"\u003e\u003cem\u003eSources cited in this description and in the In Vitro \u0026amp; In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e [1]. \u003ca target=\"_blank\" rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29091570\"\u003eRichard S Finkel, et al. Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy. N Engl J Med. 2017 Nov 2;377(18):1723-1732.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e [2]. \u003ca target=\"_blank\" rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31230718\"\u003eLaura Torres-Benito, et al. NCALD Antisense Oligonucleotide Therapy in Addition to Nusinersen further Ameliorates Spinal Muscular Atrophy in Mice. Am J Hum Genet. 2019 Jul 3;105(1):221-230.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e [3]. \u003ca target=\"_blank\" rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32612161\/\"\u003eBerciano MT, et al. Nusinersen ameliorates motor function and prevents motoneuron Cajal body disassembly and abnormal poly(A) RNA distribution in a SMA mouse model. Sci Rep. 2020 Jul 1;10(1):10738.\u003c\/a\u003e\u003c\/p\u003e\n\u003ch2\u003eSafety\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003e\u003cp\u003e\u003cstrong\u003eFor Research Use Only.\u003c\/strong\u003e Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.\u003c\/p\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"MedChemExpress (MCE)","offers":[{"title":"1 mg","offer_id":67604860273005,"sku":"HY-112980-1MG","price":454.0,"currency_code":"USD","in_stock":true},{"title":"5 mg","offer_id":67605057143149,"sku":"HY-112980-5MG","price":1164.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":67605057175917,"sku":"HY-112980-10MG","price":1680.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":67605057208685,"sku":"HY-112980-50MG","price":3744.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":67605057241453,"sku":"HY-112980-100MG","price":5242.0,"currency_code":"USD","in_stock":true},{"title":"200 mg","offer_id":67605057274221,"sku":"HY-112980-200MG","price":0.0,"currency_code":"USD","in_stock":true},{"title":"500 mg","offer_id":67605057306989,"sku":"HY-112980-500MG","price":0.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.ebiohippo.com\/products\/nusinersen-bhb21900297","provider":"BioHippo","version":"1.0","type":"link"}