{"product_id":"o-glcnac-antibody-bha11905331","title":"MOLECULAR SIGNATURE® O-GlcNAc Antibody","description":"\u003cp\u003eO-GlcNAcylation is a reversible post-translational modification involving the attachment of N-acetylglucosamine (GlcNAc) to serine and threonine residues of nuclear and cytoplasmic proteins. This modification, catalyzed by O-GlcNAc transferase (OGT) and removed by O-GlcNAcase (OGA), plays a critical role in neuronal signaling, transcriptional regulation, and proteostasis.\u003c\/p\u003e\n\n\u003cp\u003eIn the central nervous system, O-GlcNAcylation modulates synaptic plasticity, axonal transport, and stress responses. It acts as a nutrient and stress sensor, integrating metabolic status with cellular function. Dysregulation of O-GlcNAc cycling has been implicated in several neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s disease.\u003c\/p\u003e\n\n\u003cp\u003eIn Alzheimer’s disease, reduced O-GlcNAcylation correlates with increased tau hyperphosphorylation and aggregation, contributing to neurofibrillary tangle formation. Enhancing O-GlcNAc levels has been shown to reduce tau pathology and improve cognitive function in preclinical models. Similarly, in Parkinson’s disease, O-GlcNAcylation influences α-synuclein aggregation and mitochondrial function.\u003c\/p\u003e\n\n\u003cp\u003eGiven its broad regulatory scope and neuroprotective potential, O-GlcNAcylation is emerging as a promising therapeutic target. Pharmacological modulation of OGT and OGA activity is under investigation for restoring proteostasis and mitigating neurodegenerative progression.\u003c\/p\u003e\n\n\u003cp\u003eAs a dynamic and responsive signaling mechanism, O-GlcNAcylation bridges metabolism, stress adaptation, and neuronal health—making it a focal point in the search for disease-modifying interventions in neurodegeneration.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug \/ Unconjugated","offer_id":53040791519597,"sku":"SMC-502D","price":417.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 390","offer_id":53040862069101,"sku":"SMC-502D-A390","price":472.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 488","offer_id":53040862101869,"sku":"SMC-502D-A488","price":471.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 594","offer_id":53040862134637,"sku":"SMC-502D-A594","price":471.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ APC","offer_id":53040862167405,"sku":"SMC-502D-APC","price":470.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ BI","offer_id":53040862200173,"sku":"SMC-502D-BI","price":467.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ FITC","offer_id":53040862232941,"sku":"SMC-502D-FITC","price":462.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ HRP","offer_id":53040862265709,"sku":"SMC-502D-HRP","price":458.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ PCP","offer_id":53040862298477,"sku":"SMC-502D-PCP","price":470.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ RPE","offer_id":53040862331245,"sku":"SMC-502D-RPE","price":468.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040862364013,"sku":"SMC-502S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SMC-502_O-GlcNAc_Antibody_9H6_ICC-IF_Human_Embryonic-kidney-cells-HEK293_Composite_1.png?v=1771832162","url":"https:\/\/www.ebiohippo.com\/products\/o-glcnac-antibody-bha11905331","provider":"BioHippo","version":"1.0","type":"link"}