{"product_id":"oat1-antibody-organic-anion-transporter-1-slc22a6-bha17135513","title":"OAT1 Antibody \/ Organic anion transporter 1 \/ SLC22A6","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eOAT1 Antibody \/ Organic anion transporter 1 \/ SLC22A6 is a anti-OAT1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as ELISA, Flow cytometry (FACS), Western blot (WB) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e OAT1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e ELISA, FACS, WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eOAT1 antibody detects Organic anion transporter 1, a renal membrane transporter responsible for the uptake of a wide range of endogenous metabolites and xenobiotics. OAT1 plays a vital role in drug excretion, toxin clearance, and metabolic waste handling. The OAT1 antibody is used in nephrology, pharmacology, and toxicology research to study renal secretion, drug-drug interactions, and kidney function.\u003cbr\u003e\u003cbr\u003eOAT1 is encoded by the SLC22A6 gene located on human chromosome 11q12.3. The protein is approximately 563 amino acids long and belongs to the solute carrier 22 family. OAT1 is expressed predominantly in the basolateral membrane of renal proximal tubule cells, where it mediates the uptake of organic anions from the bloodstream into tubular cells, enabling their secretion into urine via apical transporters.\u003cbr\u003e\u003cbr\u003eThe OAT1 antibody detects a 60 kilodalton band by western blot and shows basolateral membrane staining in kidney tissue sections. OAT1 transports metabolites such as urate, prostaglandins, and p-aminohippurate, as well as drugs including antivirals, diuretics, and antibiotics. Its activity depends on the transmembrane exchange of alpha-ketoglutarate, coupling organic anion uptake to cellular metabolism.\u003cbr\u003e\u003cbr\u003eBecause OAT1 handles many pharmaceuticals, it is a major determinant of drug pharmacokinetics and toxicity. Inhibition or saturation of OAT1 can lead to altered drug clearance and nephrotoxicity. Genetic polymorphisms in OAT1 affect drug response variability and susceptibility to renal injury. Beyond renal physiology, OAT1 contributes to organic acid homeostasis in the brain and choroid plexus.\u003cbr\u003e\u003cbr\u003eBy regulating solute movement between blood and urine, OAT1 maintains chemical balance and metabolic detoxification.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=OAT1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=OAT1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=OAT1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/OAT1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=OAT1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047294001517,"sku":"FY12610","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_fe2205ef-8f93-49f4-92de-879e62feb0ec.jpg?v=1782237034","url":"https:\/\/www.ebiohippo.com\/products\/oat1-antibody-organic-anion-transporter-1-slc22a6-bha17135513","provider":"BioHippo","version":"1.0","type":"link"}