{"product_id":"oaz1-antibody-ornithine-decarboxylase-antizyme-1-bha17136119","title":"OAZ1 Antibody \/ Ornithine decarboxylase antizyme 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eOAZ1 Antibody \/ Ornithine decarboxylase antizyme 1 is a anti-OAZ1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Flow cytometry (FACS) with listed reactivity in Human. Reported localization: Cytoplasmic, Nuclear.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e OAZ1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, FACS\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eOAZ1 antibody detects Ornithine decarboxylase antizyme 1, a regulatory protein that controls cellular polyamine levels by inhibiting ornithine decarboxylase (ODC) and polyamine uptake. The UniProt recommended name is Ornithine decarboxylase antizyme 1 (OAZ1). This protein plays a key role in maintaining intracellular polyamine homeostasis, which is essential for cell growth, differentiation, and apoptosis. OAZ1 functions as a feedback regulator that ensures balance between biosynthesis and transport of polyamines such as putrescine, spermidine, and spermine.\u003cbr\u003e\u003cbr\u003eFunctionally, OAZ1 antibody identifies a 228-amino-acid cytoplasmic protein that binds to and inhibits the enzyme ODC, preventing the conversion of ornithine into putrescine, the first step in polyamine biosynthesis. OAZ1 also targets ODC for ubiquitin-independent proteasomal degradation, ensuring rapid turnover of the enzyme. Additionally, OAZ1 regulates polyamine transport across the plasma membrane by binding to polyamine importers and blocking uptake. These dual inhibitory actions maintain tight control of intracellular polyamine concentrations.\u003cbr\u003e\u003cbr\u003eThe OAZ1 gene is located on chromosome 19p13.3 and is expressed in nearly all tissues, with high levels in liver, brain, and reproductive organs. OAZ1 translation is uniquely regulated by a +1 ribosomal frameshifting mechanism triggered by elevated polyamine concentrations, creating an autoregulatory feedback loop that modulates its own synthesis in response to metabolic conditions.\u003cbr\u003e\u003cbr\u003ePathologically, dysregulation of OAZ1 contributes to cancer, neurodegeneration, and reproductive disorders. Reduced OAZ1 activity leads to elevated polyamine levels that promote uncontrolled cell proliferation, while overexpression can suppress tumor growth by restricting polyamine availability. In the nervous system, OAZ1 influences synaptic plasticity and neuronal differentiation. Research using OAZ1 antibody supports studies in metabolic regulation, cancer biology, and neurophysiology.\u003cbr\u003e\u003cbr\u003eOAZ1 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect polyamine regulators. \u003cbr\u003e\u003cbr\u003eStructurally, Ornithine decarboxylase antizyme 1 consists of a conserved ODC-binding region that mediates enzyme inhibition and a C-terminal domain required for proteasomal targeting. The protein's structure allows it to act both as an inhibitor and degradation adaptor without requiring ubiquitin conjugation. This antibody enables detailed investigation of OAZ1's role in polyamine metabolism, feedback control, and tumor suppression.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=OAZ1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=OAZ1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=OAZ1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/OAZ1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=OAZ1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047318446445,"sku":"FY13217","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_199cb9a6-1983-4a92-a58b-06ed64f2135a.jpg?v=1782237068","url":"https:\/\/www.ebiohippo.com\/products\/oaz1-antibody-ornithine-decarboxylase-antizyme-1-bha17136119","provider":"BioHippo","version":"1.0","type":"link"}