{"product_id":"ostm1-antibody-osteopetrosis-associated-transmembrane-protein-1-bha17135680","title":"OSTM1 Antibody \/ Osteopetrosis-associated transmembrane protein 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eOSTM1 Antibody \/ Osteopetrosis-associated transmembrane protein 1 is a anti-OSTM1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF) with listed reactivity in Human. Reported localization: Nuclear, cytoplasmic.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e OSTM1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC\/IF\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eOSTM1 antibody detects Osteopetrosis-associated transmembrane protein 1, a lysosomal membrane protein essential for osteoclast function and bone resorption. Encoded by the OSTM1 gene on chromosome 6q21, this protein forms a complex with the chloride channel CLCN7, stabilizing its localization and activity within lysosomal and ruffled-border membranes. The OSTM1-CLCN7 complex is critical for acidification and ion exchange in osteoclasts, processes that drive bone matrix degradation and remodeling. Loss of OSTM1 function results in autosomal recessive osteopetrosis, characterized by dense but brittle bones and defective osteoclast activity.\u003cbr\u003e\u003cbr\u003eOSTM1 contains a single transmembrane domain and a large luminal glycoprotein region that protects lysosomal membranes from degradation. It plays a dual role as a chaperone for CLCN7 and as a structural component of lysosomal and endosomal membranes. In addition to skeletal tissues, OSTM1 is expressed in neurons and immune cells, where it contributes to lysosomal biogenesis and degradation of cellular material. Its deficiency leads to impaired lysosomal trafficking, abnormal autophagy, and neurodegeneration.\u003cbr\u003e\u003cbr\u003eThe OSTM1 antibody is widely used in bone biology, lysosomal function, and neurodegeneration research to study protein trafficking, osteoclast activity, and lysosomal integrity. Western blot analysis identifies a 40-50 kilodalton band corresponding to glycosylated OSTM1, while immunofluorescence reveals punctate lysosomal localization that colocalizes with LAMP1 and CLCN7. This antibody supports detailed studies of lysosomal acidification, bone remodeling, and cellular degradation pathways.\u003cbr\u003e\u003cbr\u003eBeyond osteoclast biology, OSTM1 influences autophagic flux and neuronal survival through regulation of lysosomal enzyme maturation and pH balance. The OSTM1 antibody provides an effective tool for exploring the cellular mechanisms underlying osteopetrosis, lysosomal storage disorders, and neurodegenerative diseases.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=OSTM1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=OSTM1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=OSTM1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/OSTM1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=OSTM1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047303143789,"sku":"FY12777","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_67c573bd-b59e-451c-93a4-91476349549d.jpg?v=1782237056","url":"https:\/\/www.ebiohippo.com\/products\/ostm1-antibody-osteopetrosis-associated-transmembrane-protein-1-bha17135680","provider":"BioHippo","version":"1.0","type":"link"}