{"product_id":"otud4-antibody-otu-domain-containing-protein-4-bha17135776","title":"OTUD4 Antibody \/ OTU domain-containing protein 4","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eOTUD4 Antibody \/ OTU domain-containing protein 4 is a anti-OTUD4 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Nuclear, cytoplasmic.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e OTUD4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC\/IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eOTUD4 antibody detects OTU domain-containing protein 4, a deubiquitinating enzyme that regulates protein stability, DNA damage response, and innate immunity. Encoded by the OTUD4 gene on chromosome 4q31.23, this enzyme belongs to the ovarian tumor (OTU) family of cysteine proteases that cleave ubiquitin chains from substrate proteins. OTUD4 maintains cellular protein homeostasis by removing polyubiquitin modifications that target proteins for proteasomal degradation.\u003cbr\u003e\u003cbr\u003eStructurally, OTUD4 contains an OTU catalytic domain with conserved cysteine and histidine residues required for thiol protease activity. It also possesses multiple ubiquitin-binding motifs that enable recognition of specific ubiquitin linkages, conferring substrate selectivity. OTUD4 localizes to both cytoplasm and nucleus, where it modulates key signaling proteins involved in stress response, interferon signaling, and genome maintenance.\u003cbr\u003e\u003cbr\u003eThe OTUD4 antibody is widely used in ubiquitin signaling, oncology, and immunology research to study protein degradation, stability, and DNA repair. Western blot analysis identifies an approximately 130 kilodalton band corresponding to OTUD4, while immunofluorescence reveals both cytoplasmic and nuclear punctate localization, consistent with its regulatory role in ubiquitin metabolism. This antibody enables detection of dynamic changes in ubiquitin-modifying enzymes during stress and immune signaling.\u003cbr\u003e\u003cbr\u003eFunctionally, OTUD4 stabilizes DNA repair proteins such as KU80 and RPA1, promoting efficient double-strand break repair. It also regulates antiviral responses by modulating the ubiquitination of MAVS and other interferon signaling components, thereby balancing antiviral defense and immune homeostasis. Loss or mutation of OTUD4 impairs genome integrity and contributes to increased sensitivity to genotoxic stress. In cancer, dysregulated OTUD4 expression affects tumor cell proliferation and chemoresistance by altering protein turnover and checkpoint signaling. The OTUD4 antibody provides an essential tool for exploring deubiquitination pathways and their role in cell signaling and genomic maintenance.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=OTUD4 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=OTUD4 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=OTUD4 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/OTUD4 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=OTUD4+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047304454509,"sku":"FY12874","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_cd3f0453-8974-4a14-929d-492ffeec5c17.jpg?v=1782237058","url":"https:\/\/www.ebiohippo.com\/products\/otud4-antibody-otu-domain-containing-protein-4-bha17135776","provider":"BioHippo","version":"1.0","type":"link"}