{"product_id":"p38-antibody-bha11907001","title":"p38 Antibody","description":"\u003cp\u003ep38 is a member of the mitogen-activated protein kinase (MAPK) family, specifically involved in cellular responses to stress and inflammation. In the nervous system, p38 plays a pivotal role in regulating apoptosis, neuroinflammation, and synaptic plasticity—processes that are frequently dysregulated in neurodegenerative diseases.\u003c\/p\u003e\n\n\u003cp\u003eUpon activation by environmental and cellular stressors such as oxidative damage, cytokines, and UV radiation, p38 translocates to the nucleus where it modulates transcription factors and pro-apoptotic proteins. This leads to the release of cytochrome c, activation of caspase-3, and cleavage of PARP, promoting programmed cell death.\u003c\/p\u003e\n\n\u003cp\u003eIn Alzheimer’s, Parkinson’s, and ALS, aberrant p38 signaling contributes to neuronal loss, glial activation, and neurodegenerative phenotypes. As a result, p38 has emerged as a therapeutic target for modulating neuroinflammation and preventing neuronal degeneration.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 uL \/ Unconjugated","offer_id":53040793289069,"sku":"SPC-172D","price":235.0,"currency_code":"USD","in_stock":true},{"title":"100 uL \/ ATTO 390","offer_id":53040870293869,"sku":"SPC-172D-A390","price":290.0,"currency_code":"USD","in_stock":true},{"title":"100 uL \/ ATTO 488","offer_id":53040870326637,"sku":"SPC-172D-A488","price":289.0,"currency_code":"USD","in_stock":true},{"title":"100 uL \/ ATTO 594","offer_id":53040870359405,"sku":"SPC-172D-A594","price":289.0,"currency_code":"USD","in_stock":true},{"title":"100 uL \/ APC","offer_id":53040870392173,"sku":"SPC-172D-APC","price":288.0,"currency_code":"USD","in_stock":true},{"title":"100 uL \/ BI","offer_id":53040870424941,"sku":"SPC-172D-BI","price":284.0,"currency_code":"USD","in_stock":true},{"title":"100 uL \/ FITC","offer_id":53040870457709,"sku":"SPC-172D-FITC","price":279.0,"currency_code":"USD","in_stock":true},{"title":"100 uL \/ HRP","offer_id":53040870490477,"sku":"SPC-172D-HRP","price":275.0,"currency_code":"USD","in_stock":true},{"title":"100 uL \/ PCP","offer_id":53040870523245,"sku":"SPC-172D-PCP","price":288.0,"currency_code":"USD","in_stock":true},{"title":"100 uL \/ RPE","offer_id":53040870556013,"sku":"SPC-172D-RPE","price":285.0,"currency_code":"USD","in_stock":true},{"title":"12 uL \/ Unconjugated","offer_id":53040870588781,"sku":"SPC-172S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SPC-172_p38_Antibody_ICC-IF_Human_HeLa-Cells_100x_Composite.png?v=1771832155","url":"https:\/\/www.ebiohippo.com\/products\/p38-antibody-bha11907001","provider":"BioHippo","version":"1.0","type":"link"}