{"product_id":"palld-antibody-palladin-bha17136055","title":"PALLD Antibody \/ Palladin","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePALLD Antibody \/ Palladin is a anti-PALLD Rabbit antibody Recombinant Rabbit Monoclonal clone 31P55 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PALLD\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 31P55, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePALLD antibody detects Palladin, encoded by the PALLD gene. Palladin is a cytoskeletal protein that plays a central role in actin organization, cell migration, and adhesion. It functions as a scaffold that links actin filaments to signaling molecules and structural proteins, helping cells maintain shape and mobility. PALLD antibody provides researchers with an important reagent to study cytoskeletal remodeling, development, and cancer progression.\u003cbr\u003e\u003cbr\u003ePalladin is expressed in many tissues and exists in multiple isoforms generated by alternative splicing. Research using PALLD antibody has shown that it localizes to stress fibers, focal adhesions, and cell junctions, where it promotes actin crosslinking and interaction with other actin-binding proteins. This scaffolding role is essential for coordinated cytoskeletal dynamics during development, wound healing, and tissue remodeling.\u003cbr\u003e\u003cbr\u003eIn cancer biology, Palladin has emerged as a driver of tumor invasion and metastasis. Studies with PALLD antibody have demonstrated that elevated expression enhances actin remodeling, enabling cancer cells to migrate and invade surrounding tissues. In pancreatic cancer, Palladin is strongly upregulated, where it promotes formation of invasive protrusions. Conversely, depletion of Palladin reduces tumor cell motility and invasiveness, underscoring its pathogenic role.\u003cbr\u003e\u003cbr\u003eBeyond oncology, Palladin is important for embryonic development and organogenesis. Research using PALLD antibody has revealed that knockout of Palladin in mice results in embryonic lethality due to defects in organ and vascular formation. Its role in fibroblast function, extracellular matrix remodeling, and smooth muscle contractility further emphasizes its significance in development and physiology.\u003cbr\u003e\u003cbr\u003ePALLD antibody is widely applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting demonstrates multiple isoforms, immunohistochemistry shows tissue distribution, and immunofluorescence reveals colocalization with actin filaments. These applications make PALLD antibody indispensable for studies of cytoskeletal structure and signaling.\u003cbr\u003e\u003cbr\u003eBy supplying validated PALLD antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=PALLD - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PALLD - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PALLD - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/PALLD - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PALLD+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047314121069,"sku":"FY13153","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_dc2db850-fc14-4a7c-bd6a-4dd620c31ac7.jpg?v=1772019403","url":"https:\/\/www.ebiohippo.com\/products\/palld-antibody-palladin-bha17136055","provider":"BioHippo","version":"1.0","type":"link"}