{"product_id":"palvanil-bhb21300269","title":"Palvanil","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e N-(4-hydroxy-3-methoxybenzyl)palmitamide.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 69693-13-6\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C24H41NO3.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 5 nM - 5 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e DMSO 10 mM. Centrifuge all product preparations before use (10000 x g for 1 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TRPV1 channels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e Palvanil activates TRPV1 channels at 100 nM in a slower manner than capsaicin1.\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eTransient receptor potential vanilloid receptor 1 (TRPV1) is a non-selective cation channel that is stimulated by capsaicin, protons, endogenous lipids, and hot temperature. Upon activation, TRPV1 initiates a signaling cascade that results in elevated levels of pain-inducing factors. It is located in sensory ganglia composed of neurons that send projection throughout the periphery1.N-palmitoyl-vanillamide (palvanil) is a TRPV1 agonist, a non-poignant analogue to capsaicin (capsaicinoid). It has a slower kinetic opening-onset than capsaicin, but it activates the channel more potently. It induces significantly milder side effects - e.g. imbalanced thermal homeostasis and bronchoconstriction - than capsaicin, and it seems to be suitable as a topical anti-analgesic. It is effective in reducing edema2, and can inhibit inflammatory and neuropathic pain3, and interestingly, in vitro data have shown that at low concentrations it encourages the proliferation of osteoclasts, and does the opposite at high concentrations4.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249712456045,"sku":"P-205-10MG-1","price":168.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311570510189,"sku":"P-205-25MG-1","price":373.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311570542957,"sku":"P-205-5MG-1","price":117.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311570575725,"sku":"P-205-50MG-1","price":680.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/P-205_gr.gif?v=1778544444","url":"https:\/\/www.ebiohippo.com\/products\/palvanil-bhb21300269","provider":"BioHippo","version":"1.0","type":"link"}