{"product_id":"pc-9-cell-bhc11101127","title":"PC-9 cell","description":"The PC-9 cell line is derived from a human lung adenocarcinoma, a subtype of non-small cell lung cancer (NSCLC). This cell line is particularly notable for harboring an activating mutation in the EGFR gene, specifically the exon 19 deletion (E746_A750del), which is a common driver mutation in NSCLC. This alteration makes PC-9 an invaluable model for studying the biology of EGFR-driven cancers and evaluating the efficacy of tyrosine kinase inhibitors (TKIs) like gefitinib and erlotinib, which specifically target this pathway.\n\nPC-9 cells have been extensively used in research focused on resistance mechanisms to EGFR TKIs, particularly the emergence of secondary mutations like T790M. These studies have informed the development of third-generation inhibitors such as osimertinib, which target both the primary EGFR mutation and resistance-associated alterations. The cell line also exhibits sensitivity to other inhibitors targeting downstream signaling pathways, including those involved in PI3K\/AKT and MAPK signaling cascades, underscoring its utility in translational cancer research.\n\nIn addition to its genetic and pharmacological attributes, PC-9 has been incorporated into high-throughput drug screening programs, facilitating the identification of compounds with selective activity against EGFR-mutated NSCLC. The line's well-characterized genomic landscape and consistent phenotypic behavior in vitro make it a cornerstone for both basic and applied lung cancer research, particularly in the context of targeted and combination therapy.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101127\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950221226349,"sku":"305045","price":550.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/PC-9_20P_20X_20305045-M_2020x01_202_2024.11.2022_1920x1920_eb87a31f-7f3e-4d82-890e-56f694efa787.jpg?v=1769069193","url":"https:\/\/www.ebiohippo.com\/products\/pc-9-cell-bhc11101127","provider":"BioHippo","version":"1.0","type":"link"}