{"product_id":"pctp-antibody-phosphatidylcholine-transfer-protein-bha17136280","title":"PCTP Antibody \/ Phosphatidylcholine transfer protein","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePCTP Antibody \/ Phosphatidylcholine transfer protein is a anti-PCTP Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB) with listed reactivity in Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PCTP\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePCTP antibody detects Phosphatidylcholine transfer protein, a lipid transport protein encoded by the PCTP gene on chromosome 17q11.2. PCTP belongs to the START (steroidogenic acute regulatory protein-related lipid transfer) domain family and is responsible for the intermembrane transfer of phosphatidylcholine, a major phospholipid component of cell membranes. PCTP is highly expressed in liver, macrophages, and skeletal muscle, where it contributes to lipid trafficking, membrane homeostasis, and metabolic regulation. It plays a key role in coordinating lipid transport with energy metabolism, particularly during fasting and lipid oxidation processes.\u003cbr\u003e\u003cbr\u003eStructurally, PCTP is a small soluble protein containing a single START domain that forms a hydrophobic cavity for phosphatidylcholine binding. This structure allows PCTP to shuttle phospholipids between intracellular membranes, supporting membrane biogenesis and lipid signaling. It belongs to the phospholipid transfer protein family, which includes STARD2 and STARD10, and interacts with nuclear receptors such as PPAR and LXR that regulate lipid metabolism. Co-localization studies show PCTP distributed in the cytosol and associated with mitochondria and the endoplasmic reticulum.\u003cbr\u003e\u003cbr\u003eFunctionally, PCTP regulates phospholipid exchange and metabolic signaling. By transferring phosphatidylcholine between membranes, it maintains lipid composition and supports vesicular transport. PCTP also modulates the activity of thioesterase superfamily member THEM2, linking phospholipid transfer to fatty acid oxidation. In macrophages, it influences cholesterol efflux and inflammatory responses, while in hepatocytes, it contributes to VLDL assembly and secretion. PCTP participates in lipid signaling pathways that regulate glucose metabolism, energy storage, and membrane trafficking.\u003cbr\u003e\u003cbr\u003eAltered expression of PCTP has been associated with metabolic and cardiovascular diseases. Overexpression promotes lipid accumulation and insulin resistance, while deficiency enhances fatty acid oxidation and improves glucose tolerance. Pathway involvement includes phospholipid transport, lipid metabolism, and mitochondrial energy regulation. Expression of PCTP increases during metabolic stress and fasting, reflecting its role in adaptive lipid handling.\u003cbr\u003e\u003cbr\u003eThe PCTP antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=PCTP - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PCTP - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PCTP - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/PCTP - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PCTP+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047325262189,"sku":"FY13378","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_d274c96c-1af8-40fd-9364-cd3dc38aa709.jpg?v=1782237111","url":"https:\/\/www.ebiohippo.com\/products\/pctp-antibody-phosphatidylcholine-transfer-protein-bha17136280","provider":"BioHippo","version":"1.0","type":"link"}