{"product_id":"pdc-e2-antibody-pyruvate-dehydrogenase-e2-bha17136316","title":"PDC-E2 Antibody \/ Pyruvate Dehydrogenase E2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePDC-E2 Antibody \/ Pyruvate Dehydrogenase E2 is a anti-PDC-E2 Rabbit antibody Recombinant Rabbit Monoclonal clone 23D09 supplied in Purified format. Recommended for workflows such as Western blot (WB), IHC-P, Immunofluorescence (IF) with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PDC-E2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 23D09, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC-P, IF\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePyruvate dehydrogenase E2 (PDC-E2) is the dihydrolipoamide acetyltransferase component of the pyruvate dehydrogenase complex, a key mitochondrial enzyme complex linking glycolysis to the citric acid cycle. PDC-E2 catalyzes the transfer of an acetyl group from pyruvate to coenzyme A, producing acetyl-CoA for cellular energy metabolism.    \u003cp\u003ePDC-E2 is essential for efficient carbohydrate oxidation and energy production. It is also the primary autoantigen recognized in primary biliary cholangitis (PBC), an autoimmune liver disease, making it important in both metabolic and immunological research. \u003c\/p\u003e\n\u003cp\u003eUsing a high-quality PDC-E2 antibody enables accurate detection in applications such as western blot, immunohistochemistry, and ELISA. A PDC-E2 antibody from\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=PDC-E2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PDC-E2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PDC-E2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/PDC-E2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PDC-E2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047324475757,"sku":"RQ8897","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_1202bcf3-7c65-4495-9899-f03f2760694f.jpg?v=1772019445","url":"https:\/\/www.ebiohippo.com\/products\/pdc-e2-antibody-pyruvate-dehydrogenase-e2-bha17136316","provider":"BioHippo","version":"1.0","type":"link"}