{"product_id":"pde4a11-blocking-peptide-stj504622-bhp15501146","title":"PDE4A11 Blocking Peptide (STJ504622)","description":"\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-qc-badge{display:inline-block;background:#e6f4ea;color:#1a7a3c;border:1px solid #a8d5b5;border-radius:4px;padding:6px 14px;font-size:14px;font-weight:600}\n.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}\n.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\n\u003c\/style\u003e\n\u003cdiv class=\"bhp-desc\"\u003e\n\u003ch2\u003eScientific Background\u003c\/h2\u003e\n\u003cp\u003ePhosphodiesterase 4A11 (PDE4A11) is a long-form cAMP-specific phosphodiesterase encoded by \u003cem\u003ePDE4A\u003c\/em\u003e. PDE4 enzymes are major regulators of intracellular cAMP levels in immune and neuronal cells, controlling inflammatory signalling downstream of beta-adrenergic and prostaglandin receptors. PDE4 inhibitors such as roflumilast are approved for COPD and psoriasis therapy.\u003c\/p\u003e\n\u003ch2\u003eProduct Description\u003c\/h2\u003e\n\u003cspan class=\"bhp-cat-pill\"\u003eBlocking \/ Competition Peptide\u003c\/span\u003e\n\u003cp\u003eThis synthetic peptide corresponds to the immunogen sequence used to raise the matched St John's Laboratory antibody. It is supplied for immunodepletion and immunocompetition experiments to confirm antibody binding specificity. Pre-incubating the antibody with this peptide before immunoassay use abolishes or substantially reduces target-specific signal.\u003c\/p\u003e\n\n\u003ch2\u003eProduct Specifications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n  \u003ctr\u003e\n\u003cth\u003eUniProt ID\u003c\/th\u003e\n\u003ctd\u003eP27815\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003ctr\u003e\n\u003cth\u003eImmunogen\u003c\/th\u003e\n\u003ctd\u003eSynthetic peptide taken within amino acid region 50-100 on human PDE4A11 protein.\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003ctr\u003e\n\u003cth\u003eImmunogen Region (aa)\u003c\/th\u003e\n\u003ctd\u003e50-100\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003ctr\u003e\n\u003cth\u003eFormulation\u003c\/th\u003e\n\u003ctd\u003eLiquid form at 2.5mg\/ml concentration in PBS. Up to 5% DMSO can be added. Orders with \u0026gt;1mg can be supplied in lyophilized powder form, or in buffer of choice.\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003eStore at-20°C for long term storage. Avoid freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003ctr\u003e\n\u003cth\u003eApplications\u003c\/th\u003e\n\u003ctd\u003eImmunodepletion, Immunocompetition\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003ch2\u003eRecommended Protocol\u003c\/h2\u003e\n\u003cp\u003eIncubate the paired antibody (at working concentration) with a 5–10 molar excess of this peptide for 30–60 minutes at 4°C or room temperature. Centrifuge briefly if any precipitate forms, then use the pre-absorbed antibody in parallel with an unblocked control in the same experiment. Abolition or substantial reduction of signal confirms antibody specificity to the target epitope.\u003c\/p\u003e\n\u003ch2\u003eSafety \u0026amp; Handling\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003e\u003cp\u003eSTRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.\u003c\/p\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"St John's Laboratory Ltd","offers":[{"title":"250 ug","offer_id":53326596473197,"sku":"STJ504622-250","price":359.49,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/product-no-image_c01e07c8-c6c2-4e3a-bdf4-59a1bc21362c.png?v=1778704892","url":"https:\/\/www.ebiohippo.com\/products\/pde4a11-blocking-peptide-stj504622-bhp15501146","provider":"BioHippo","version":"1.0","type":"link"}