{"product_id":"pdgfb-antibody-platelet-derived-growth-factor-subunit-b-bha17136072","title":"PDGFB Antibody \/ Platelet derived growth factor subunit B","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePDGFB Antibody \/ Platelet derived growth factor subunit B is a anti-PDGFB Rabbit antibody Recombinant Rabbit Monoclonal clone 31P34 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PDGFB\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 31P34, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePDGFB antibody detects Platelet derived growth factor subunit B, encoded by the PDGFB gene. Platelet derived growth factor subunit B is a growth factor that dimerizes to form homodimers or heterodimers with the PDGFA subunit, creating PDGF-BB or PDGF-AB ligands. These ligands bind to platelet derived growth factor receptors, initiating signaling cascades that control proliferation, survival, and migration of mesenchymal cells. PDGFB antibody provides researchers with a specific reagent to study angiogenesis, wound healing, and cancer biology.\u003cbr\u003e\u003cbr\u003ePlatelet derived growth factor subunit B is secreted as part of a larger precursor protein that undergoes proteolytic processing to yield the mature growth factor. Research using PDGFB antibody has demonstrated that PDGF-BB is a potent mitogen for fibroblasts, vascular smooth muscle cells, and pericytes. Its signaling regulates blood vessel development and maintenance, making it essential for embryonic angiogenesis and adult vascular remodeling. Knockout models lacking PDGFB develop severe vascular abnormalities, underscoring its importance in development.\u003cbr\u003e\u003cbr\u003eAberrant expression of Platelet derived growth factor subunit B has been linked to a wide range of diseases. Studies with PDGFB antibody have shown that overexpression promotes tumor growth and angiogenesis by stimulating stromal proliferation and vascular recruitment. In fibrotic disease, excess PDGFB drives fibroblast activation and extracellular matrix deposition. Conversely, deficiency in PDGFB signaling results in defective pericyte recruitment and fragile vasculature. These findings demonstrate its critical role in tissue integrity and pathology.\u003cbr\u003e\u003cbr\u003ePDGFB also contributes to neurobiology. Research using PDGFB antibody has revealed that the protein supports neural progenitor proliferation and protects neurons from injury through trophic signaling. Dysregulation has been associated with neurodegenerative conditions and gliomas. Because of its diverse functions across tissues, Platelet derived growth factor subunit B remains an important therapeutic target.\u003cbr\u003e\u003cbr\u003ePDGFB antibody is widely applied in western blotting, immunohistochemistry, and ELISA. Western blotting detects mature and precursor forms, immunohistochemistry highlights expression in vasculature and tumors, and ELISA quantifies secreted PDGFB in biological fluids. These applications make PDGFB antibody valuable in both basic and translational research.\u003cbr\u003e\u003cbr\u003eBy supplying validated PDGFB antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=PDGFB - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PDGFB - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PDGFB - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/PDGFB - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PDGFB+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047313793389,"sku":"FY13170","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_3115b584-4c7c-4803-9f6b-9806c5ffb2fe.jpg?v=1772019404","url":"https:\/\/www.ebiohippo.com\/products\/pdgfb-antibody-platelet-derived-growth-factor-subunit-b-bha17136072","provider":"BioHippo","version":"1.0","type":"link"}