{"product_id":"pdia4-antibody-protein-disulfide-isomerase-a4-erp72-bha17136139","title":"PDIA4 Antibody \/ Protein disulfide-isomerase A4 \/ ERp72","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePDIA4 Antibody \/ Protein disulfide-isomerase A4 \/ ERp72 is a anti-PDIA4 Rabbit antibody Recombinant Rabbit Monoclonal clone 32P79 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PDIA4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 32P79, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePDIA4 antibody detects Protein disulfide-isomerase A4, also known as ERp72, encoded by the PDIA4 gene. Protein disulfide-isomerase A4 is an endoplasmic reticulum resident enzyme that catalyzes the formation, isomerization, and reduction of disulfide bonds in nascent proteins. PDIA4 antibody provides researchers with a robust reagent to study protein folding, quality control, and endoplasmic reticulum function.\u003cbr\u003e\u003cbr\u003eProtein disulfide-isomerase A4 is a member of the protein disulfide-isomerase family, characterized by thioredoxin-like domains that mediate redox reactions. Research using PDIA4 antibody has shown that ERp72 interacts with a wide range of substrates, ensuring correct disulfide bond formation during protein maturation. This activity contributes to protein stability and function, making PDIA4 essential for secretory pathway homeostasis.\u003cbr\u003e\u003cbr\u003ePDIA4 also plays a role in the unfolded protein response. Studies with PDIA4 antibody have demonstrated that its expression increases during endoplasmic reticulum stress, reflecting a need for enhanced protein folding capacity. By assisting in protein quality control, PDIA4 protects cells from accumulation of misfolded proteins and prevents activation of apoptosis pathways triggered by unresolved stress.\u003cbr\u003e\u003cbr\u003eBeyond folding, Protein disulfide-isomerase A4 has been linked to calcium homeostasis and chaperone activity. Research using PDIA4 antibody has suggested that ERp72 participates in calcium binding and contributes to regulation of calcium dependent processes in the endoplasmic reticulum. These functions underscore the multifunctional nature of PDIA4 in cellular physiology.\u003cbr\u003e\u003cbr\u003eDysregulation of PDIA4 is associated with disease. Elevated expression has been observed in cancers, where increased folding capacity supports tumor cell survival under stress. Conversely, mutations or impaired function may contribute to protein misfolding disorders. Research using PDIA4 antibody has revealed roles in neurodegeneration, diabetes, and cardiovascular disease, reflecting its broad importance across pathologies.\u003cbr\u003e\u003cbr\u003ePDIA4 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects ER localized PDIA4, immunohistochemistry highlights expression in secretory tissues, and immunofluorescence reveals endoplasmic reticulum distribution. These applications make PDIA4 antibody a valuable tool in cell biology and disease research.\u003cbr\u003e\u003cbr\u003eBy supplying validated PDIA4 antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=PDIA4 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PDIA4 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PDIA4 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/PDIA4 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PDIA4+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047319691629,"sku":"FY13237","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_4049ab5d-e9ff-458a-9553-fde1e131a130.jpg?v=1772019411","url":"https:\/\/www.ebiohippo.com\/products\/pdia4-antibody-protein-disulfide-isomerase-a4-erp72-bha17136139","provider":"BioHippo","version":"1.0","type":"link"}