{"product_id":"pdlim4-antibody-pdz-and-lim-domain-protein-4-bha17135530","title":"PDLIM4 Antibody \/ PDZ and LIM domain protein 4","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePDLIM4 Antibody \/ PDZ and LIM domain protein 4 is a anti-PDLIM4 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Flow cytometry (FACS), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PDLIM4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC, IF, IP, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePDLIM4 antibody detects PDZ and LIM domain protein 4, a cytoskeletal adaptor protein that links actin filaments to signaling complexes and transcriptional regulators. PDLIM4 is a member of the PDZ and LIM domain protein family, characterized by modular domains that mediate interactions between cytoskeletal components and signaling molecules. The PDLIM4 antibody is widely used in cell biology, oncology, and musculoskeletal research to study actin dynamics, cell differentiation, and tumor suppression.\u003cbr\u003e\u003cbr\u003ePDLIM4 is encoded by the PDLIM4 gene located on human chromosome 5q31.1. The protein is approximately 330 amino acids long and contains a PDZ domain that binds actin-associated proteins and a LIM domain that mediates interactions with kinases and transcriptional regulators. PDLIM4 localizes primarily to actin stress fibers and focal adhesions, where it contributes to cytoskeletal organization and mechanotransduction.\u003cbr\u003e\u003cbr\u003eThe PDLIM4 antibody detects a 36 kilodalton band by western blot and shows filamentous cytoplasmic staining under immunofluorescence microscopy. Functionally, PDLIM4 serves as a scaffold linking cytoskeletal tension to gene expression pathways involved in differentiation and proliferation. It interacts with alpha-actinin, integrins, and protein kinase C, coordinating mechanical and biochemical signals during cell adhesion and migration.\u003cbr\u003e\u003cbr\u003ePDLIM4 also acts as a tumor suppressor and has been reported to be downregulated or epigenetically silenced in several cancers, including prostate and breast carcinoma. Restoration of PDLIM4 expression suppresses cell growth and induces apoptosis, suggesting its role in controlling oncogenic transformation. Beyond cancer, PDLIM4 contributes to osteoblast differentiation and bone remodeling by regulating cytoskeletal integrity and mechanical signaling.\u003cbr\u003e\u003cbr\u003eBecause of its dual role in cytoskeletal architecture and transcriptional regulation, PDLIM4 serves as a critical link between cellular mechanics and gene expression.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=PDLIM4 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PDLIM4 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PDLIM4 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/PDLIM4 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PDLIM4+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047294886253,"sku":"FY12627","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_15d5f8a8-a0b2-432a-985e-0e013c5b82ad.jpg?v=1782237021","url":"https:\/\/www.ebiohippo.com\/products\/pdlim4-antibody-pdz-and-lim-domain-protein-4-bha17135530","provider":"BioHippo","version":"1.0","type":"link"}