{"product_id":"pdzd8-antibody-pdz-domain-containing-protein-8-bha17136195","title":"PDZD8 Antibody \/ PDZ domain-containing protein 8","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003ePDZD8 Antibody \/ PDZ domain-containing protein 8 is a anti-PDZD8 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Nucleus, Cytoplasm (Golgi), Cell membrane.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e PDZD8\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003ePDZD8 antibody targets PDZ domain-containing protein 8, a membrane-associated scaffolding protein involved in organelle tethering, lipid transfer, and calcium signaling. Encoded by the PDZD8 gene, this multidomain protein contains PDZ, C1, and coiled-coil regions that mediate interactions with multiple organelle and cytoskeletal proteins. PDZD8 plays a crucial role in forming membrane contact sites between the endoplasmic reticulum (ER) and mitochondria, facilitating lipid exchange and calcium ion transport essential for energy metabolism and cellular homeostasis.\u003cbr\u003e\u003cbr\u003eRecent studies have shown that PDZD8 acts as a functional ortholog of yeast Mmm1-Mdm12 complex components in establishing ER-mitochondrial contacts. By bridging the two organelles, PDZD8 helps coordinate mitochondrial dynamics and calcium uptake during neuronal signaling and metabolic activity. Loss of PDZD8 disrupts mitochondrial morphology, impairs synaptic transmission, and affects neuronal energy balance, highlighting its importance in brain physiology. The protein is also implicated in autophagy regulation, as it contributes to the spatial organization of membrane contact sites during autophagosome formation.\u003cbr\u003e\u003cbr\u003eThe PDZD8 gene is located on chromosome 10q25.3 and encodes multiple isoforms through alternative splicing. The protein localizes to the ER membrane via its C-terminal transmembrane domain and interacts with small GTPases and lipid transport proteins. Dysregulation of PDZD8 has been associated with neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and Huntington's disease, where altered organelle tethering and calcium imbalance contribute to pathogenesis.\u003cbr\u003e\u003cbr\u003eImmunohistochemical staining using PDZD8 antibody reveals perinuclear and cytoplasmic localization in neurons, hepatocytes, and fibroblasts. The antibody is valuable for investigating ER-mitochondrial contact formation, calcium signaling, and membrane lipid metabolism. PDZD8 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=PDZD8 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PDZD8 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PDZD8 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/PDZD8 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=PDZD8+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047321854317,"sku":"FY13293","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_86256d9b-93f8-40a0-ab7c-6377a85389b8.jpg?v=1782237092","url":"https:\/\/www.ebiohippo.com\/products\/pdzd8-antibody-pdz-domain-containing-protein-8-bha17136195","provider":"BioHippo","version":"1.0","type":"link"}