{"product_id":"peaqx-tetrasodium-hydrate-bhb21300272","title":"PEAQX tetrasodium hydrate","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e tetrasodium;5-[[[(1S)-1-(4-bromophenyl)ethyl]amino]-phosphonatomethyl]quinoxaline-2,3-diolate;hydrate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso known as:\u003c\/strong\u003e NVP-AAM077\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 459836-30-7\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C17H15BrN3Na4O6P.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;95%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 10 nM - 1 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e 100 mM in water. Centrifuge all product preparations before use (10,000 x g for 1 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Centrifuge the vial before adding solvent (10,000 x g for 5 minutes). The lyophilizate may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. Soluble in DMSO. Prepare a concentrated stock solution by dissolving the lyophilized peptide in DMSO first (e.g., at a concentration between 100-1000x of the final working concentration). Once the peptide is completely dissolved in DMSO, slowly dilute the solution into the working buffer (or water) to the desired final working concentration. Centrifuge all product preparations before use. It is recommended to keep the DMSO concentration as low as possible. For cell assays, a final concentration of 0.1%–0.5% DMSO (v\/v) is considered safe. For other experiments, a 5% DMSO (v\/v) concentration is recommended\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NR1, NR2 receptors\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e PEAQX is an NMDA receptor antagonist1.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names:\u003c\/strong\u003e NVP-AAM077\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003ePEAQX tetrasodium hydrate (NVP-AAM007) is a competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor. This compound shows higher selectivity for NR2A over NR2B subunit-containing receptor. PEAQX IC50 values are strongly dependent on agonist concentration used to evoke response. IC50 for NR1\/NR2A were 31 ± 2 nM for EC50 of glutamate, and 214 ± 10 nM for 10-times the EC50 of glutamate. IC50 values for NR1\/NR2B were significantly higher: 215 ± 13 nM and 2.2 ± 0.14 μM for EC50 and 10-times the EC50 of glutamate, respectively1.Several studies claim that PEAQX has the ability to cause a blockade of adult long-term potentiation while only moderately affecting juvenile long-term potentiation. It was shown that subsaturating concentrations of APV (a NMDAR antagonist) can imitate the effects of PEAQX on long-term potentiation. These findings suggest that the synaptic plasticity affected by PEAQX can be explained by nonspecific blockade of NMDA receptors2.NMDA receptors play an important role in a variety of cellular processes and brain functions such as synaptic plasticity, addiction and stroke. NMDA receptors mediate several physiological functions including learning and memory formation; they play a role in glutamate excitotoxicity and are involved in many neurodegenerative conditions including Alzheimer's disease3.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249712750957,"sku":"P-255-10MG-1","price":306.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311571493229,"sku":"P-255-25MG-1","price":670.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311571525997,"sku":"P-255-5MG-1","price":193.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311571558765,"sku":"P-255-50MG-1","price":1036.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/P-255_gr.gif?v=1778544449","url":"https:\/\/www.ebiohippo.com\/products\/peaqx-tetrasodium-hydrate-bhb21300272","provider":"BioHippo","version":"1.0","type":"link"}