{"product_id":"pepjet-in-vivo-dna-transfection-reagent-bht2200035","title":"PepJet™ In Vivo DNA Transfection Reagent","description":"\u003cdiv class=\"bhp-desc\"\u003e\n\u003cstyle\u003e.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}.bhp-desc p{margin:0 0 12px}.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}.bhp-desc .bhp-figure{margin:16px 0 20px;text-align:center}.bhp-desc .bhp-figure img{max-width:100%;height:auto;display:block;margin:0 auto 6px}.bhp-desc .bhp-figure figcaption{font-size:14px;color:#444;text-align:left;line-height:1.5}.bhp-desc .bhp-data-table th{width:auto}.bhp-desc .bhp-data-table td{font-size:14px}\u003c\/style\u003e\n\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cp\u003eAt the heart of PepJet™ In Vivo DNA Transfection Reagent sits a synthetic 28-amino-acid peptide, picked out originally by screening as a potent nucleic acid delivery vehicle and then refined with sequence alignment, molecular modeling, and computational analyses that took their cue from naturally occurring viral protein architectures. Chemical synthesis, structural refinement, and repeated rounds of in vitro and in vivo validation followed, all aimed at wringing the most gene transfer efficiency out of it; what resulted is a next-generation cationic peptide–based delivery system engineered for highly efficient plasmid DNA transfection in vivo. A proprietary shielding peptide is covalently built into the platform for better systemic stability and biological performance: it cuts down nonspecific interactions with serum proteins and other biological components once the material is given systemically, so PepJet™\/DNA complexes form, hold together, and distribute better.\u003c\/p\u003e\n\u003cp\u003eAnimal studies using systemic administration have shown efficient plasmid DNA delivery and robust transgene expression across several organs — lung, liver, spleen, and kidney.\u003c\/p\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eTransfection Type\u003c\/th\u003e\n\u003ctd\u003eIn Vivo Transfection\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eApplication Setting\u003c\/th\u003e\n\u003ctd\u003eIn Vivo\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePre-Optimized\u003c\/th\u003e\n\u003ctd\u003eNo — General-Purpose Formulation\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003eStore at 4°C. When maintained under the recommended storage conditions, PepJet™ DNA In Vivo Transfection Reagent is stable for at least 24 months.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003ch2\u003ePerformance Data\u003c\/h2\u003e\n\u003cfigure class=\"bhp-figure\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/signagen-PepJet_In_Vivo.webp?v=1790173498\" alt=\"PepJet™ In Vivo DNA Transfection Reagent – Renilla luciferase in mouse lung, liver, spleen and kidney after systemic delivery\" loading=\"lazy\"\u003e\u003cfigcaption\u003eThe in vivo transfection efficiency of PepJet™ reagent was evaluated in mice using a plasmid encoding Renilla luciferase as a reporter gene. Following systemic administration of PepJet™\/DNA complexes, transgene expression levels were quantified in various organs to assess tissue distribution and gene delivery efficiency. PepJet™ mediated robust Renilla luciferase expression in the lung, liver, spleen, and kidney, demonstrating its effectiveness as a systemic plasmid DNA delivery platform.\u003c\/figcaption\u003e\u003c\/figure\u003e\u003ch2\u003eApplications\u003c\/h2\u003e\n\u003cp\u003eSuitable for in vivo gene delivery applications including gene therapy research, in vivo reporter assays, and preclinical studies. Consult the product datasheet for recommended dosing and administration routes.\u003c\/p\u003e\n\u003ch2\u003eSafety \u0026amp; Handling\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003e\n\u003cstrong\u003eFor Research Use Only (RUO)\u003c\/strong\u003e — Not for diagnostic or therapeutic use. Handle reagents according to institutional biosafety guidelines. Refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.\u003c\/div\u003e\n\u003c\/div\u003e","brand":"SignaGen Laboratories","offers":[{"title":"0.1 mL","offer_id":54042899415405,"sku":"SL100501-0P1ML","price":29.0,"currency_code":"USD","in_stock":true},{"title":"0.5 mL","offer_id":54042904559981,"sku":"SL100501-0P5ML","price":146.0,"currency_code":"USD","in_stock":true},{"title":"1.0 mL","offer_id":54042904592749,"sku":"SL100501-1P0ML","price":278.0,"currency_code":"USD","in_stock":true},{"title":"1.0 mL x 5","offer_id":54042904625517,"sku":"SL100501-1P0MLX5","price":1320.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/signagen-PepJet_In_Vivo_cadb97c7-edda-4c65-bd26-0ee74feddc5b.webp?v=1790175948","url":"https:\/\/www.ebiohippo.com\/products\/pepjet-in-vivo-dna-transfection-reagent-bht2200035","provider":"BioHippo","version":"1.0","type":"link"}